Drug General Information
Drug ID
D09PZD
Former ID
DIB021160
Drug Name
viral macrophage inflammatory protein-II
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542659]
Structure
Download
2D MOL
Formula
C55H93N19O14S2
InChI
InChI=1S/C55H93N19O14S2/c1-28(2)23-37-50(84)74-43(30(5)75)52(86)69-35(15-9-10-20-56)47(81)67-33(16-11-21-63-54(59)60)45(79)65-25-41(77)66-34(17-12-22-64-55(61)62)46(80)68-36(18-19-40(58)76)48(82)73-42(29(3)4)51(85)72-39(53(87)88)27-90-89-26-32(57)44(78)70-38(49(83)71-37)24-31-13-7-6-8-14-31/h6-8,13-14,28-30,32-39,42-43,75H,9-12,15-27,56-57H2,1-5H3,(H2,58,76)(H,65,79)(H,66,77)(H,67,81)(H,68,80)(H,69,86)(H,70,78)(H,71,83)(H,72,85)(H,73,82)(H,74,84)(H,87,88)(H4,59,60,63)(H4,61,62,64)/t30-,32+,33+,34+,35+,36+,37+,38+,39+,42+,43+/m1/s1
InChIKey
JOEHPBQVSCDCHE-BKGQOYFSSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) CC chemokine receptor Target Info Antagonist [534456]
C-X-C chemokine receptor 4 Target Info Antagonist [534456]
C-C chemokine receptor type 8 Target Info Antagonist [525544]
C-C chemokine receptor type 2 Target Info Antagonist [534456]
mRNA of CCR5 Target Info Antagonist [534456]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathwayhsa04060:Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Axon guidance
Leukocyte transendothelial migration
Intestinal immune network for IgA production
Pathways in cancerhsa04060:Cytokine-cytokine receptor interaction
Viral carcinogenesishsa04060:Cytokine-cytokine receptor interaction
Toxoplasmosis
Viral carcinogenesis
NetPath Pathway IL2 Signaling Pathway
IL4 Signaling Pathway
Leptin Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling PathwayNetPath_24:TSLP Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Axon guidance mediated by Slit/Robo
Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database S1P3 pathway
CXCR4-mediated signaling events
Syndecan-4-mediated signaling events
HIF-1-alpha transcription factor network
Ephrin B reverse signalingil12_2pathway:IL12-mediated signaling events
Reactome Beta defensins
Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling eventsR-HSA-173107:Binding and entry of HIV virion
G alpha (i) signalling eventsR-HSA-380108:Chemokine receptors bind chemokines
G alpha (i) signalling eventsR-HSA-1461957:Beta defensins
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
Hematopoietic Stem Cell Differentiation
HIV Life Cycle
Cardiac Progenitor Differentiation
Defensins
Spinal Cord Injury
GPCR downstream signalingWP69:TCR Signaling Pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 542659(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 768).
Ref 525544HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines. J Biol Chem. 1999 Jul 30;274(31):21569-74.
Ref 534456A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science. 1997 Sep 12;277(5332):1656-9.

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