Drug Information

Drug General Information
Drug ID
D09JHM
Former ID
DNC014280
Drug Name
N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530473]
Structure
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2D MOL

3D MOL
Formula
C15H12ClN3O
Canonical SMILES
COC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Cl
InChI
1S/C15H12ClN3O/c1-20-12-5-6-14-13(8-12)15(18-9-17-14)19-11-4-2-3-10(16)7-11/h2-9H,1H3,(H,17,18,19)
InChIKey
JDEKFVYZUIPHET-UHFFFAOYSA-N
PubChem Compound ID
19595108
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [530473]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 530473Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. Epub 2009 Oct 9.Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.
Ref 530473Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. Epub 2009 Oct 9.Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.

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