Drug Information
Drug General Information | |||||
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Drug ID |
D08YHD
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Former ID |
DNC004653
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Drug Name |
1,1,1-Trifluoro-7-phenylheptan-2-one
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Synonyms |
1,1,1-Trifluoro-7-phenyl-heptan-2-one
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [529843] | ||
Structure |
Download2D MOL |
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Formula |
C13H15F3O
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Canonical SMILES |
C1=CC=C(C=C1)CCCCCC(=O)C(F)(F)F
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InChI |
1S/C13H15F3O/c14-13(15,16)12(17)10-6-2-5-9-11-7-3-1-4-8-11/h1,3-4,7-8H,2,5-6,9-10H2
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InChIKey |
OYIOJJUJKLHWGM-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Cytosolic phospholipase A2 | Target Info | Inhibitor | [529843] | |
Fatty-acid amide hydrolase | Target Info | Inhibitor | [527476] | ||
BioCyc Pathway | PhospholipasesPWY6666-1:Anandamide degradation | ||||
KEGG Pathway | Glycerophospholipid metabolism | ||||
Ether lipid metabolism | |||||
Arachidonic acid metabolism | |||||
Linoleic acid metabolism | |||||
alpha-Linolenic acid metabolism | |||||
Metabolic pathways | |||||
MAPK signaling pathway | |||||
Ras signaling pathway | |||||
Vascular smooth muscle contraction | |||||
VEGF signaling pathway | |||||
Platelet activation | |||||
Fc epsilon RI signaling pathway | |||||
Fc gamma R-mediated phagocytosis | |||||
Glutamatergic synapse | |||||
Serotonergic synapse | |||||
Long-term depression | |||||
Inflammatory mediator regulation of TRP channels | |||||
GnRH signaling pathway | |||||
Ovarian steroidogenesis | |||||
Oxytocin signaling pathway | |||||
Choline metabolism in cancerhsa04723:Retrograde endocannabinoid signaling | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | ||||
Endothelins | |||||
PDGFR-beta signaling pathway | |||||
Signaling mediated by p38-alpha and p38-beta | |||||
PathWhiz Pathway | Fc Epsilon Receptor I Signaling in Mast Cells | ||||
References | |||||
Ref 527476 | J Med Chem. 2005 Mar 24;48(6):1849-56.Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. | ||||
Ref 529843 | J Med Chem. 2008 Dec 25;51(24):8027-37.Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. |
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