| Drug General Information |
| Drug ID |
D08QXD
|
| Former ID |
DIB020177
|
| Drug Name |
L-783483
|
| Synonyms |
F3MethylAA
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C22H21ClF3NO4S
|
| InChI |
InChI=1S/C22H21ClF3NO4S/c1-2-4-14-17(7-6-15-20(14)31-27-21(15)22(24,25)26)30-9-3-10-32-18-8-5-13(11-16(18)23)12-19(28)29/h5-8,11H,2-4,9-10,12H2,1H3,(H,28,29)
|
| InChIKey |
TZBRFAASYWFUGK-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
|
| Target and Pathway |
| Target(s) |
mRNA of PPAR-gamma |
Target Info |
Agonist |
[2]
|
|---|
| Oxysterols receptor LXR-alpha |
Target Info |
Agonist |
[3]
|
| Peroxisomeproliferator activated receptor delta |
Target Info |
Agonist |
[2]
|
| Oxysterols receptor LXR-beta |
Target Info |
Agonist |
[3]
|
|
KEGG Pathway
|
PPAR signaling pathway
|
|
AMPK signaling pathway
|
|
Osteoclast differentiation
|
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Huntington's disease
|
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Pathways in cancer
|
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Transcriptional misregulation in cancer
|
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Thyroid cancerhsa03320:PPAR signaling pathway
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|
Non-alcoholic fatty liver disease (NAFLD)
|
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Hepatitis Chsa03320:PPAR signaling pathway
|
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Wnt signaling pathway
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Acute myeloid leukemia
|
|
NetPath Pathway
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IL1 Signaling Pathway
|
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TGF_beta_Receptor Signaling Pathway
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Leptin Signaling PathwayNetPath_14:IL2 Signaling Pathway
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PANTHER Pathway
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CCKR signaling map STP00057:Wnt signaling pathway
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Pathway Interaction Database
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Noncanonical Wnt signaling pathway
|
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
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Signaling events mediated by HDAC Class I
|
|
RXR and RAR heterodimerization with other nuclear receptor
|
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Regulation of retinoblastoma proteinrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptorps1pathway:Presenilin action in Notch and Wnt signaling
|
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RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
|
|
Reactome
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PPARA activates gene expression
|
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Transcriptional regulation of white adipocyte differentiation
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Nuclear Receptor transcription pathwayR-HSA-200425:Import of palmitoyl-CoA into the mitochondrial matrix
|
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Regulation of pyruvate dehydrogenase (PDH) complex
|
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Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
|
|
WikiPathways
|
Wnt Signaling Pathway Netpath
|
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Nuclear Receptors in Lipid Metabolism and Toxicity
|
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Differentiation of white and brown adipocyte
|
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Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
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Transcriptional Regulation of White Adipocyte Differentiation
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Adipogenesis
|
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SREBP signalling
|
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Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
|
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Nuclear Receptors Meta-Pathway
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PPAR Alpha Pathway
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Liver X Receptor Pathway
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SREBF and miR33 in cholesterol and lipid homeostasis
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Nuclear ReceptorsWP399:Wnt Signaling Pathway and Pluripotency
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NRF2 pathway
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Vitamin D Receptor Pathway
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Ectoderm Differentiation
|
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Nuclear ReceptorsWP1982:SREBP signalling
|
|
Nuclear Receptors
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2688). |
|---|
| REF 2 | Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. J Biol Chem. 1999 Mar 5;274(10):6718-25. |
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| REF 3 | A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). Endocrinology. 2002 Jul;143(7):2548-58. |
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