Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08NNR
|
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| Former ID |
DIB011002
|
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| Drug Name |
Testosterone glucoside
|
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| Synonyms |
S-403-G
|
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| Indication | Hypogonadism [ICD9: 257.2; ICD10:E23.0, E28.3, E29.1] | Discontinued in Phase 2 | [1] | ||
| Company |
Strakan Group plc
|
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
O([C@@H]1[C@@]2([C@H]([C@H]3[C@@H]([C@@]4(C(=CC(=O)CC4)<br />CC3)C)CC2)CC1)C)C1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O
|
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| Target and Pathway | |||||
| Target(s) | Androgen receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | Oocyte meiosis | ||||
| Pathways in cancer | |||||
| Prostate cancer | |||||
| NetPath Pathway | EGFR1 Signaling Pathway | ||||
| AndrogenReceptor Signaling Pathway | |||||
| FSH Signaling Pathway | |||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
| Coregulation of Androgen receptor activity | |||||
| Regulation of Androgen receptor activity | |||||
| Nongenotropic Androgen signaling | |||||
| Regulation of nuclear beta catenin signaling and target gene transcription | |||||
| FOXA1 transcription factor network | |||||
| Notch-mediated HES/HEY network | |||||
| Reactome | Nuclear Receptor transcription pathway | ||||
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Integrated Pancreatic Cancer Pathway | |||||
| Prostate Cancer | |||||
| Integrated Breast Cancer Pathway | |||||
| Nuclear Receptors | |||||
| Androgen receptor signaling pathway | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018266) | ||||
| REF 2 | Evidence for a role of testosterone-androgen receptor interactions in mediating masculine sexual behavior in male rats. Endocrinology. 1989 Feb;124(2):618-26. | ||||
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