Drug General Information
Drug ID	D08DQZ
Former ID	DNC012000
Drug Name	4-Methyl-oxazolidin-(2Z)-ylideneamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[526912]
Structure		Download 2D MOL 3D MOL
Formula	C4H8N2O
Canonical SMILES	CC1COC(=N1)N
InChI	1S/C4H8N2O/c1-3-2-7-4(5)6-3/h3H,2H2,1H3,(H2,5,6)
InChIKey	PIXPFRMNXPKTFS-UHFFFAOYSA-N
PubChem Compound ID	18376830
Target and Pathway
Target(s)	Nitric-oxide synthase, brain	Target Info	Inhibitor	[526912]
	Nitric oxide synthase, inducible	Target Info	Inhibitor	[526912]
BioCyc Pathway	Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
KEGG Pathway	Arginine and proline metabolism
	Metabolic pathways
	Calcium signaling pathway
	Phagosome
	Circadian entrainment
	Long-term depression
	Salivary secretion
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)hsa00220:Arginine biosynthesis
	HIF-1 signaling pathway
	Peroxisome
	Salmonella infection
	Pertussis
	Leishmaniasis
	Chagas disease (American trypanosomiasis)
	Toxoplasmosis
	Amoebiasis
	Tuberculosis
	Pathways in cancer
	Small cell lung cancer
NetPath Pathway	EGFR1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
	IL2 Signaling Pathway
PANTHER Pathway	CCKR signaling map ST
Pathway Interaction Database	IL12-mediated signaling events
	Alpha9 beta1 integrin signaling events
	ATF-2 transcription factor network
	IL23-mediated signaling events
	Signaling mediated by p38-alpha and p38-beta
	HIF-1-alpha transcription factor network
PathWhiz Pathway	Arginine and Proline Metabolism
Reactome	ROS production in response to bacteria
	Nitric oxide stimulates guanylate cyclaseR-HSA-1222556:ROS production in response to bacteria
	Nitric oxide stimulates guanylate cyclase
WikiPathways	Monoamine Transport
	Myometrial Relaxation and Contraction Pathways
	Amyotrophic lateral sclerosis (ALS)
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Spinal Cord Injury
	Alzheimers Disease
	Effects of Nitric Oxide
	Serotonin Transporter ActivityWP619:Type II interferon signaling (IFNG)
	AGE/RAGE pathway
References
Ref 526912	Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6.4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor.
Ref 526912	Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6.4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor.

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