Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07DBS
|
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| Former ID |
DIB005076
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| Drug Name |
RP-64477
|
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| Indication | Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] | Discontinued in Phase 2 | [1] | ||
| Company |
Rhone-Poulenc SA
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| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
C(=O)(Nc1cc(C(=O)NCCCC)ccc1SC)c1ccc(cc1)OCCCCCCCCCC
|
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| CAS Number |
CAS 135239-65-5
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| Target and Pathway | |||||
| Target(s) | Liver carboxylesterase | Target Info | Modulator | [2] | |
| KEGG Pathway | Drug metabolism - other enzymes | ||||
| Metabolic pathways | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Heroin metabolism | |||||
| Irinotecan Pathway | |||||
| Fluoropyrimidine Activity | |||||
| Phase I biotransformations, non P450 | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002301) | ||||
| REF 2 | RP 64477: a potent inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase with low systemic bioavailability. Biochem Pharmacol. 1996 Feb 23;51(4):413-21. | ||||
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