TTD | Drug: D06ZWG

Drug General Information
Drug ID	D06ZWG
Former ID	DCL000709
Drug Name	AVE-5997EF
Drug Type	Small molecular drug
Indication	Schizophrenia [ICD9: 295; ICD10:F20]		Terminated	[536463]
Company	Sanofi-Aventis
Structure		Download 2D MOL 3D MOL
Formula	C25H29F3N4OS
Canonical SMILES	CC1=CC=C(C=C1)NC(=O)NCCCCN2CCN(CC2)C3=CSC4=C3C=CC(=C4)C<br />(F)(F)F
InChI	1S/C25H29F3N4OS/c1-18-4-7-20(8-5-18)30-24(33)29-10-2-3-11-31-12-14-32(15-13-31)22-17-34-23-16-19(25(26,27)28)6-9-21(22)23/h4-9,16-17H,2-3,10-15H2,1H3,(H2,29,30,33)
InChIKey	XVFIYMFVLGFALY-UHFFFAOYSA-N
PubChem Compound ID	9891761
PubChem Substance ID	14859499, 24177161, 45638696, 76986272, 85210255, 134339209, 140392538, 231469148, 247132902
Target and Pathway
Target(s)	D(3) dopamine receptor	Target Info	Antagonist	[536463]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	Dopaminergic synapse
Reactome	Dopamine receptors
Reactome	G alpha (i) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
	GPCRs, Other
References
Ref 536463	The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 536463	The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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Drug Information