Drug General Information
Drug ID	D06UBB
Former ID	DNC003956
Drug Name	SK&F-86466
Synonyms	SK-86466
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533638]
Structure		Download 2D MOL 3D MOL
Formula	C11H14ClN
Canonical SMILES	CN1CCC2=C(CC1)C(=CC=C2)Cl
InChI	1S/C11H14ClN/c1-13-7-5-9-3-2-4-11(12)10(9)6-8-13/h2-4H,5-8H2,1H3
InChIKey	RSRUDTPYRBLHEO-UHFFFAOYSA-N
PubChem Compound ID	123981
Target and Pathway
Target(s)	Alpha-1A adrenergic receptor	Target Info	Inhibitor	[533638]
	Alpha-1D adrenergic receptor	Target Info	Inhibitor	[533638]
	Alpha-1B adrenergic receptor	Target Info	Inhibitor	[533638]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	AMPK signaling pathway
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretionhsa04020:Calcium signaling pathway
	Salivary secretion
NetPath Pathway	IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database	LPA receptor mediated events
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
	AMPK SignalingWP58:Monoamine GPCRs
	GPCRs, OtherWP58:Monoamine GPCRs
	Vitamin D Receptor Pathway
	AMPK Signaling
References
Ref 533638	J Med Chem. 1995 Sep 15;38(19):3681-716.Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.
Ref 533638	J Med Chem. 1995 Sep 15;38(19):3681-716.Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.

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