Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06FCR
|
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| Former ID |
DIB000982
|
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| Drug Name |
CL-277082
|
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| Drug Type |
Small molecular drug
|
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| Indication | Arteriosclerosis [ICD9: 440; ICD10:I70] | Discontinued in Phase 1 | [1] | ||
| Company |
Lederle Laboratories
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C26H36F2N2O
|
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| Canonical SMILES |
C(=O)(Nc1c(cc(cc1)F)F)N(Cc1ccc(CC(C)(C)C)cc1)CCCCCCC
|
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| CAS Number |
CAS 96224-26-9
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Liver carboxylesterase | Target Info | Modulator | [2] | |
| KEGG Pathway | Drug metabolism - other enzymes | ||||
| Metabolic pathways | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Heroin metabolism | |||||
| Irinotecan Pathway | |||||
| Fluoropyrimidine Activity | |||||
| Phase I biotransformations, non P450 | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001648) | ||||
| REF 2 | CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption. J Lipid Res. 1989 May;30(5):681-90. | ||||
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