| Drug General Information |
| Drug ID |
D05LSB
|
| Former ID |
DIB002886
|
| Drug Name |
COX-2 inhibitors
|
| Synonyms |
Anti-inflammatories, FAES Farma; COX-2 inhibitors, FAES Farma; Cyclooxygenase-2 inhibitor, FAES Farma
|
| Indication |
Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25]
|
Investigative |
[1]
|
|---|
| Company |
FAES Farma SA
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
O=S(=O)(c1ccc(c2nc(cc(C(F)(F)F)n2)NCc2ccccc2)cc1)C
|
| Target and Pathway |
| Target(s) |
Prostaglandin G/H synthase 2 |
Target Info |
Inhibitor |
[2]
|
|---|
|
BioCyc Pathway
|
Aspirin-triggered lipoxin biosynthesis
|
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Aspirin triggered resolvin D biosynthesis
|
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C20 prostanoid biosynthesis
|
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Aspirin triggered resolvin E biosynthesis
|
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KEGG Pathway
|
Arachidonic acid metabolism
|
|
Metabolic pathways
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NF-kappa B signaling pathway
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VEGF signaling pathway
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TNF signaling pathway
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Retrograde endocannabinoid signaling
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Serotonergic synapse
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Ovarian steroidogenesis
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Oxytocin signaling pathway
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Regulation of lipolysis in adipocytes
|
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Leishmaniasis
|
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Pathways in cancer
|
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Chemical carcinogenesis
|
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MicroRNAs in cancer
|
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Small cell lung cancer
|
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NetPath Pathway
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IL1 Signaling Pathway
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TSH Signaling Pathway
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IL4 Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
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IL5 Signaling Pathway
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PANTHER Pathway
|
Endothelin signaling pathway
|
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Inflammation mediated by chemokine and cytokine signaling pathway
|
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Toll receptor signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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S1P1 pathway
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C-MYB transcription factor network
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Signaling mediated by p38-alpha and p38-beta
|
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Calcium signaling in the CD4+ TCR pathway
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PathWhiz Pathway
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Arachidonic Acid Metabolism
|
|
WikiPathways
|
Prostaglandin Synthesis and Regulation
|
|
Arachidonic acid metabolism
|
|
Aryl Hydrocarbon Receptor
|
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
|
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Spinal Cord Injury
|
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Integrated Pancreatic Cancer Pathway
|
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Eicosanoid Synthesis
|
|
Selenium Micronutrient Network
|
| References |
| REF 1 | Novel 2-(4-methylsulfonylphenyl)pyrimidine derivatives as highly potent and specific COX-2 inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2183-99. Epub 2007 Dec 5. |
|---|
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1376). |
|---|
