Drug General Information
Drug ID	D04ODQ
Former ID	DIB006853
Drug Name	447C88
Synonyms	BW-447C88
Indication	Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78]		Discontinued in Phase 1	[545135]
Company	GlaxoSmithKline Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c(cc(cc1CCc1ccc(CC(C)(C)C)cc1)F)F)NC(=O)NCCCCCCC
CAS Number	CAS 130400-16-7
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Modulator	[534137]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 545135	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002257)
Ref 534137	The tolerability, pharmacokinetics and lack of effect on plasma cholesterol of 447C88, an AcylCoA: Cholesterol Acyl Transferase (ACAT) inhibitor with low bioavailability, in healthy volunteers. Eur JClin Pharmacol. 1995;49(3):243-9.

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