Drug General Information
Drug ID
D03EHR
Former ID
DIB002869
Drug Name
Lecimibide
Synonyms
DuP-128
Drug Type
Small molecular drug
Indication Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] Terminated [545142]
Company
Bristol-Myers Squibb Pharma Co
Structure
Download
2D MOL

3D MOL

Formula
C34H40F2N4OS
Canonical SMILES
c1(c([nH]c(n1)SCCCCCN(C(=O)Nc1c(cc(cc1)F)F)CCCCCCC)c1cc<br />ccc1)c1ccccc1
CAS Number
CAS 130804-35-2
PubChem Compound ID
Target and Pathway
Target(s) Liver carboxylesterase Target Info Modulator [533861]
KEGG Pathway Drug metabolism - other enzymes
Metabolic pathways
Pathway Interaction Database E2F transcription factor network
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Heroin metabolism
Irinotecan Pathway
Fluoropyrimidine Activity
Phase I biotransformations, non P450
References
Ref 545142Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002283)
Ref 533861Effect of the acyl-CoA:cholesterol acyltransferase inhibitor DuP 128 on cholesterol absorption and serum cholesterol in humans. Clin Pharmacol Ther. 1994 Jul;56(1):65-74.

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