Drug General Information
Drug ID	D03CHA
Former ID	DIB011968
Drug Name	CB1 antagonists
Synonyms	CB1 antagonists (metabolic syndrome); CB1 antagonists (metabolic syndrome), Esteve
Indication	Metabolic disorders [ICD9: 270-279; ICD10:E70-E89]		Investigative	[552166]
Company	Esteve
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(ccc(cc1Cl)Cl)N1[C@@H]([C@@H](C(=N1)C(=O)NN1[C@@H](CC<br />C[C@@H]1C)C)C)c1ccc(cc1)Cl.Cl
Target and Pathway
Target(s)	Cannabinoid receptor 1	Target Info	Antagonist	[543877]
KEGG Pathway	Rap1 signaling pathway
	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
PANTHER Pathway	Endogenous cannabinoid signaling
Pathway Interaction Database	N-cadherin signaling events
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	BDNF signaling pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 552166	WO patent application no. 2005020992, NOVEL MEDICAL USE OF SELECTIVE CB1-RECEPTOR ANTAGONISTS.
Ref 543877	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56).

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