Drug General Information
Drug ID
D02WIW
Former ID
DAP001068
Drug Name
Dexbrompheniramine
Synonyms
Dexbromfeniramina; Dexbrompheniraminum; Ilvin; Parabromodylamine; D-Brompheniramine; Dexbromfeniramina [INN-Spanish]; Dexbrompheniramine [INN:BAN]; Dexbrompheniraminum [INN-Latin]; Drixoral (TN); N,N-Dimethyl-(3-(4-bromphenyl)-3-(2-pyridyl)propyl)amin; (+)-brompheniraminum; (3-p-Bromphenyl-3-pyrid-2'-ylpropyl)dimethylamin; (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine; (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine; (S)-(+)-brompheniramine; (S)-brompheniramine
Drug Type
Small molecular drug
Indication Hay fever; Allergic rhinitis [ICD9: 477, 472.0, 995.3; ICD10:J30, J00, J31.0, T78.4] Approved [538375], [542578], [551871]
Therapeutic Class
Antihistamines
Company
Schering Corp Sub Schering Plough Corp
Structure
Download
2D MOL

3D MOL

Formula
C16H19BrN2
InChI
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1
InChIKey
ZDIGNSYAACHWNL-HNNXBMFYSA-N
CAS Number
CAS 132-21-8
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
R06AB06
SuperDrug CAS ID
cas=000132218
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [538137]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538375FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 089116.
Ref 542578(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7588).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 538137H2 histaminergic control of inhibition of eating induced by intragastric NaCl in rats. Physiol Behav. 1998 Aug;65(1):105-13.

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