Drug Information
Drug General Information | |||||
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Drug ID |
D02VFF
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Former ID |
DIB021181
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Drug Name |
VU0357121
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Synonyms |
VU 0357121
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
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Download2D MOL |
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Formula |
C17H17F2NO2
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InChI |
InChI=1S/C17H17F2NO2/c1-2-3-10-22-14-7-4-12(5-8-14)17(21)20-16-9-6-13(18)11-15(16)19/h4-9,11H,2-3,10H2,1H3,(H,20,21)
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InChIKey |
AHCYOTLTLQTPSU-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
2709194, 3533603, 5281759, 8998862, 26125026, 29792696, 49910643, 51963602, 57785811, 89274399, 111037115, 131688139, 152159618, 152258704, 160647538, 162011721, 162249080, 163323440, 163341449, 164777571, 170128066, 172087018, 172919854, 174006273, 178103015, 179352082, 185974230, 187072851, 223705402, 242060094, 252158061, 252160547, 252216595, 252553681
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Target and Pathway | |||||
Target(s) | Metabotropic glutamate receptor 5 | Target Info | Modulator (allosteric modulator) | [2] | |
KEGG Pathway | Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Gap junction | |||||
Long-term potentiation | |||||
Retrograde endocannabinoid signaling | |||||
Glutamatergic synapse | |||||
Huntington's disease | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Metabotropic glutamate receptor group III pathway | |||||
Metabotropic glutamate receptor group I pathway | |||||
Endogenous cannabinoid signaling | |||||
Reactome | G alpha (q) signalling events | ||||
Class C/3 (Metabotropic glutamate/pheromone receptors) | |||||
WikiPathways | Hypothetical Network for Drug Addiction | ||||
GPCRs, Class C Metabotropic glutamate, pheromone | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6399). | ||||
REF 2 | Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology. ACS Chem Neurosci. 2010 Oct 20;1(10):702-716. Epub 2010 Aug 19. | ||||
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