TTD | Drug: D02MBV

Drug General Information
Drug ID	D02MBV
Former ID	DIB018133
Drug Name	[123I]AM251
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[542463]
Structure		Download 2D MOL
Formula	C22H21Cl2IN4O
InChI	InChI=1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)/i25-4
InChIKey	BUZAJRPLUGXRAB-VEFBWTBNSA-N
PubChem Compound ID	10506880
PubChem Substance ID	15531866, 22828896, 41887502, 79752000, 135651097
Target and Pathway
Target(s)	Cannabinoid receptor 1	Target Info	Antagonist	[534489]
KEGG Pathway	Rap1 signaling pathway
	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
PANTHER Pathway	Endogenous cannabinoid signaling
Pathway Interaction Database	N-cadherin signaling events
Reactome	Class A/1 (Rhodopsin-like receptors)
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	BDNF signaling pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 542463	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 744).
Ref 534489	Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors. Life Sci. 1997;61(14):PL 191-7.

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Drug Information