Drug General Information
Drug ID	D02ELA
Former ID	DNC005705
Drug Name	L-NIO
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529811]
Structure		Download 2D MOL 3D MOL
Formula	C7H15N3O2
Canonical SMILES	CC(=NCCCC(C(=O)O)N)N
InChI	1S/C7H15N3O2/c1-5(8)10-4-2-3-6(9)7(11)12/h6H,2-4,9H2,1H3,(H2,8,10)(H,11,12)
InChIKey	UYZFAUAYFLEHRC-UHFFFAOYSA-N
PubChem Compound ID	107984
Target and Pathway
Target(s)	Nitric-oxide synthase, endothelial	Target Info	Inhibitor	[529811]
	Nitric oxide synthase, inducible	Target Info	Inhibitor	[529811]
	Nitric-oxide synthase, brain	Target Info	Inhibitor	[529811]
BioCyc Pathway	Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
KEGG Pathway	Arginine and proline metabolism
	Metabolic pathways
	Calcium signaling pathway
	cGMP-PKG signaling pathway
	HIF-1 signaling pathway
	Sphingolipid signaling pathway
	PI3K-Akt signaling pathway
	VEGF signaling pathway
	Platelet activation
	Estrogen signaling pathway
	Oxytocin signaling pathwayhsa00220:Arginine biosynthesis
	Peroxisome
	Salmonella infection
	Pertussis
	Leishmaniasis
	Chagas disease (American trypanosomiasis)
	Toxoplasmosis
	Amoebiasis
	Tuberculosis
	Pathways in cancer
	Small cell lung cancerhsa00330:Arginine and proline metabolism
	Phagosome
	Circadian entrainment
	Long-term depression
	Salivary secretion
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
NetPath Pathway	Wnt Signaling PathwayNetPath_13:IL1 Signaling Pathway
	IL2 Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
PANTHER Pathway	Angiogenesis
	Endothelin signaling pathway
	Interleukin signaling pathway
	PI3 kinase pathway
	VEGF signaling pathwayP06959:CCKR signaling map ST
Pathway Interaction Database	Plasma membrane estrogen receptor signaling
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	Angiopoietin receptor Tie2-mediated signaling
	Thromboxane A2 receptor signaling
	SHP2 signaling
	VEGFR1 specific signals
	Signaling events mediated by VEGFR1 and VEGFR2
	PAR1-mediated thrombin signaling eventsil12_2pathway:IL12-mediated signaling events
	Alpha9 beta1 integrin signaling events
	ATF-2 transcription factor network
	IL23-mediated signaling events
	Signaling mediated by p38-alpha and p38-beta
	HIF-1-alpha transcription factor network
PathWhiz Pathway	Arginine and Proline Metabolism
Reactome	ROS production in response to bacteria
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	eNOS activation
	Nitric oxide stimulates guanylate cyclase
	VEGFR2 mediated vascular permeabilityR-HSA-1222556:ROS production in response to bacteria
	Nitric oxide stimulates guanylate cyclaseR-HSA-1222556:ROS production in response to bacteria
WikiPathways	ACE Inhibitor Pathway
	EGF/EGFR Signaling Pathway
	Myometrial Relaxation and Contraction Pathways
	JAK/STAT
	Corticotropin-releasing hormone
	AGE/RAGE pathway
	Endothelin Pathways
	Leptin signaling pathway
	Effects of Nitric Oxide
	Metabolism of nitric oxide
	AngiogenesisWP619:Type II interferon signaling (IFNG)
	Spinal Cord Injury
	Effects of Nitric OxideWP727:Monoamine Transport
	Amyotrophic lateral sclerosis (ALS)
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Alzheimers Disease
	Serotonin Transporter Activity
References
Ref 529811	Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. Epub 2008 Oct 29.Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads.
Ref 529811	Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. Epub 2008 Oct 29.Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads.

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