Drug General Information
Drug ID	D02CKM
Former ID	DNC014416
Drug Name	N-(3-chlorophenyl)-3-cyano-5-fluorobenzamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531010]
Structure		Download 2D MOL 3D MOL
Formula	C14H8ClFN2O
Canonical SMILES	C1=CC(=CC(=C1)Cl)NC(=O)C2=CC(=CC(=C2)C#N)F
InChI	1S/C14H8ClFN2O/c15-11-2-1-3-13(7-11)18-14(19)10-4-9(8-17)5-12(16)6-10/h1-7H,(H,18,19)
InChIKey	FNDUFJARTKDXEF-UHFFFAOYSA-N
PubChem Compound ID	46911385
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[531010]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 531010	Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. Epub 2010 Jun 15.3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds withCNS exposure in rats.
Ref 531010	Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. Epub 2010 Jun 15.3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds withCNS exposure in rats.

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