| Drug General Information |
| Drug ID |
D01YEN
|
| Former ID |
DIB020031
|
| Drug Name |
ibotenate
|
| Synonyms |
ibotenic acid
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C5H6N2O4
|
| InChI |
InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
|
| InChIKey |
IRJCBFDCFXCWGO-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
12783, 565789, 5455818, 6240816, 7979560, 8140585, 8151047, 15363851, 17405212, 24277994, 24439578, 26751670, 29204271, 47365404, 47736693, 47736711, 49987522, 50104365, 50104366, 53777757, 56406882, 56463509, 57320830, 79577662, 85209396, 85231090, 90341316, 91704578, 91746333, 92304093, 99300599, 103199832, 103918448, 104297143, 118695783, 119526463, 121361487, 124749888, 124799290, 124880423, 124880424, 125539446, 128209285, 132511300, 134982726, 135652693, 136350327, 137261962, 140862532, 143856972
|
| Target and Pathway |
| Target(s) |
Metabotropicglutamate receptor 1 |
Target Info |
Agonist |
[2]
|
|---|
| Metabotropic glutamate receptor 5 |
Target Info |
Agonist |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
FoxO signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
|
Long-term potentiation
|
|
Retrograde endocannabinoid signaling
|
|
Glutamatergic synapse
|
|
Long-term depression
|
|
Estrogen signaling pathwayhsa04020:Calcium signaling pathway
|
|
Huntington's disease
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Metabotropic glutamate receptor group III pathway
|
|
Metabotropic glutamate receptor group I pathway
|
|
Endogenous cannabinoid signalingP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Endogenous cannabinoid signaling
|
|
Reactome
|
G alpha (q) signalling events
|
|
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-416476:G alpha (q) signalling events
|
|
Class C/3 (Metabotropic glutamate/pheromone receptors)
|
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
|
GPCRs, Class C Metabotropic glutamate, pheromone
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
|
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1371). |
|---|
| REF 2 | Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. |
|---|
