Drug General Information
Drug ID
D01IDE
Former ID
DIB014877
Drug Name
E-5324
Drug Type
Small molecular drug
Indication Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] Discontinued in Phase 2 [545733]
Company
Eisai Co Ltd
Structure
Download
2D MOL

3D MOL

Formula
C26H34N4O2
Canonical SMILES
n1c(c(n(c1)CCCOc1c(NC(=O)NCCCC)c(ccc1)C)CC)c1ccccc1
CAS Number
CAS 141799-76-0
PubChem Compound ID
Target and Pathway
Target(s) Liver carboxylesterase Target Info Modulator [533828]
KEGG Pathway Drug metabolism - other enzymes
Metabolic pathways
Pathway Interaction Database E2F transcription factor network
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Heroin metabolism
Irinotecan Pathway
Fluoropyrimidine Activity
Phase I biotransformations, non P450
References
Ref 545733Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004427)
Ref 533828Effect of the acyl-CoA:cholesterol acyltransferase inhibitor, E5324, on experimental atherosclerosis in rabbits. Atherosclerosis. 1994 Jun;107(2):187-201.

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