Drug Information
Drug General Information | |||||
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Drug ID |
D01ERN
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Former ID |
DIB006555
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Drug Name |
MGluR5 antagonists (anxiety), Novartis
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Synonyms |
MGluR5 antagonists (anxiety); MGluR5 antagonists (anxiety), Novartis
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Indication | Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] | Investigative | [1] | ||
Company |
Novartis AG
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Structure |
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Download2D MOL |
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Canonical SMILES |
C(=O)(N1C(CCCC1)CC)c1cnc(c(c1)Cl)Nc1cnc(cc1)C
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Target and Pathway | |||||
Target(s) | Metabotropic glutamate receptor 5 | Target Info | Antagonist | [1] | |
KEGG Pathway | Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Gap junction | |||||
Long-term potentiation | |||||
Retrograde endocannabinoid signaling | |||||
Glutamatergic synapse | |||||
Huntington's disease | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Metabotropic glutamate receptor group III pathway | |||||
Metabotropic glutamate receptor group I pathway | |||||
Endogenous cannabinoid signaling | |||||
Reactome | G alpha (q) signalling events | ||||
Class C/3 (Metabotropic glutamate/pheromone receptors) | |||||
WikiPathways | Hypothetical Network for Drug Addiction | ||||
GPCRs, Class C Metabotropic glutamate, pheromone | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293). | ||||
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