Drug Information

Drug General Information
Drug ID
D00TLN
Former ID
DAP000103
Drug Name
Cyproheptadine
Synonyms
Ciproheptadina; Ciprovit; Cypoheptadine; Cyproheptadiene; Cyproheptadinum; Dihexazin; Dronactin; Eiproheptadine; Periactin; Periactine; Periactinol; Viternum; Cyproheptadine Hcl; MK 141; Ciproheptadina [INN-Spanish]; Ciprovit (TN); Cyproheptadine (INN); Cyproheptadine [INN:BAN]; Cyproheptadinum [INN-Latin]; Dibenzosuberonone/Cyproheptadine; Periactin (TN); 1-Methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine; 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine; 4-(5-Dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine; 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidene; 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine; 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine; 4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine; 5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene
Drug Type
Small molecular drug
Indication Perennial and seasonal allergic rhinitis; Vasomotor rhinitis; Allergic conjunctivitis [ICD10:H10] Approved [551871]
Therapeutic Class
Antihistamines
Company
Merck & Co
Structure
Download
2D MOL

3D MOL
Formula
C21H21N
InChI
InChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3
InChIKey
JJCFRYNCJDLXIK-UHFFFAOYSA-N
CAS Number
CAS 129-03-3
PubChem Compound ID
2913
PubChem Substance ID
9151, 597387, 3206368, 4509244, 7979013, 8151866, 10506298, 11110964, 11110965, 11113362, 11466131, 11467251, 11485761, 14751189, 26751603, 29222066, 46508613, 47216945, 47440433, 47440434, 47515490, 47589155, 47736665, 48110626, 48110627, 48185155, 48259431, 48415832, 49698345, 50015917, 50100203, 50104260, 51092057, 78634349, 85209714, 85279540, 85787813, 85788782, 90341656, 92309316, 92729717, 93166482, 94564370, 96079554, 103173872, 103928989, 104171133, 104301985, 108667051, 116933607
SuperDrug ATC ID
R06AX02
SuperDrug CAS ID
cas=000129033
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [536089], [536720]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536089Antihistamines in the treatment of dermatitis. J Cutan Med Surg. 2003 Nov-Dec;7(6):467-73.
Ref 536720Cyproheptadine displays preclinical activity in myeloma and leukemia. Blood. 2008 Aug 1;112(3):760-9. Epub 2008 May 23.

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