Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00GHZ
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| Former ID |
DIB010384
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| Drug Name |
Antiandrogens
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| Synonyms |
Antiandrogens (prostate cancer); EM-4350; EM-5854; EM-6537; Antiandrogens (prostate cancer), Endoceutics; Androgen receptor antagonists (endocrine-related disorders), Endoceutics
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| Indication | Endocrine disease [ICD10:E00-E35] | Phase 2 | [1] | ||
| Company |
Endorecherche Inc
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
[C@@]1(Cc2cc[n+](cc2)[O-])([C@]2(CC[C@@H]3c4ccc(c(c4CC[<br />C@H]3[C@@H]2CC1)F)C#N)C)O
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| Drug Resistance Mutation (DRM) | |||||
| DRM | DRM Info | ||||
| Target and Pathway | |||||
| Target(s) | Androgen receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Oocyte meiosis | ||||
| Pathways in cancer | |||||
| Prostate cancer | |||||
| NetPath Pathway | EGFR1 Signaling Pathway | ||||
| AndrogenReceptor Signaling Pathway | |||||
| FSH Signaling Pathway | |||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
| Coregulation of Androgen receptor activity | |||||
| Regulation of Androgen receptor activity | |||||
| Nongenotropic Androgen signaling | |||||
| Regulation of nuclear beta catenin signaling and target gene transcription | |||||
| FOXA1 transcription factor network | |||||
| Notch-mediated HES/HEY network | |||||
| Reactome | Nuclear Receptor transcription pathway | ||||
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Integrated Pancreatic Cancer Pathway | |||||
| Prostate Cancer | |||||
| Integrated Breast Cancer Pathway | |||||
| Nuclear Receptors | |||||
| Androgen receptor signaling pathway | |||||
| References | |||||
| REF 1 | Phase II study of the pure non-steroidal antiandrogen nilutamide in prostatic cancer. Italian Prostatic Cancer Project (PONCAP). Eur J Cancer. 1991;27(9):1100-4. | ||||
| REF 2 | Steroid derivatives as pure antagonists of the androgen receptor. J Steroid Biochem Mol Biol. 2012 Oct;132(1-2):93-104. | ||||
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