Target General Information
Target ID T96311
Target Name NEDD8-activating enzyme E1 catalytic subunit (UBA3)
Gene Name UBA3
Species Homo sapiens
UniProt ID UBA3_HUMAN
Sequence MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST
ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI
GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI
SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA
SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR
LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER
KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS
IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS [Homo sapiens]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: I310N
Drugs
Drug Name MLN4924 Drug Info [1]
Targeted Disease Refractory hematologic malignancy
Mutation Info Missense: Y352H
Drugs
Drug Name MLN4924 Drug Info [1]
Targeted Disease Refractory hematologic malignancy
References
REF 1 Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells.PLoS One.2014 Apr 1;9(4):e93530.

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