Resistance mutation info of target
Target General Information | ||||||||||||||||||
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Target ID | T15739 | |||||||||||||||||
Target Name | Cellular tumor antigen p53 (TP53) | |||||||||||||||||
Gene Name | TP53 | |||||||||||||||||
Species | Homo sapiens | |||||||||||||||||
UniProt ID | P53_HUMAN | |||||||||||||||||
Sequence |
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD [Homo sapiens] |
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Drug and Corresponding Resistance Mutations | ||||||||||||||||||
Mutation Info | Missense: R175H + R248G | |||||||||||||||||
Drugs |
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References | ||||||||||||||||||
REF 1 | A serine 37 mutation associated with two missense mutations at highly conserved regions of p53 affect pro-apoptotic genes expression in a T-lymphoblastoid drug resistant cell line. Oncogene. 2000 Oct 19;19(44):5098-105. |
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