Target Information
| Target General Information | Top | |||||
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| Target ID |
T99092
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| Target Name |
Chloride intracellular channel protein 1 (CLIC1)
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| Synonyms |
hRNCC; Regulatory nuclear chloride ion channel protein; Nuclear chloride ion channel 27; NCC27; G6; Chloride channel ABP
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| Gene Name |
CLIC1
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
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| UniProt ID | ||||||
| Sequence |
MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCP
GGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKN SNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNL LPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKAL K Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| HIT2.0 ID | T54SRL | |||||
| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: Glutathione | Ligand Info | |||||
| Structure Description | Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione | PDB:1K0N | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [2] |
| PDB Sequence |
PQVELFVKAG
15 SDGAKIGNCP25 FSQRLFMVLW35 LKGVTFNVTT45 VDTKRRTETV55 QKLCPGGELP 65 FLLYGTEVHT75 DTNKIEEFLE85 AVLCPPRYPK95 LAALNPESNT105 AGLDIFAKFS 115 AYIKNSNPAL125 NDNLEKGLLK135 ALKVLDNYLT145 SPLPEGVSQR165 KFLDGNELTL 175 ADCNLLPKLH185 IVQVVCKKYR195 GFTIPEAFRG205 VHRYLSNAYA215 REEFASTCPD 225 DEEIELAYEQ235 VAKALK
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| Ligand Name: 3-Sulfinoalanine | Ligand Info | |||||
| Structure Description | Human CLIC1 in complex with NSC602247 | PDB:7FBQ | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [3] |
| PDB Sequence |
QPQVELFVKA
14 GSDGAKIGNP25 FSQRLFMVLW35 LKGVTFNVTT45 VDTKRRTETV55 QKLCPGGQLP 65 FLLYGTEVHT75 DTNKIEEFLE85 AVLCPPRYPK95 LAALNPESNT105 AGLDIFAKFS 115 AYIKNSNPAL125 NDNLEKGLLK135 ALKVLDNYLT145 SPLPEEVDEE158 DEGVSQRKFL 168 DGNELTLADC178 NLLPKLHIVQ188 VVCKKYRGFT198 IPEAFRGVHR208 YLSNAYAREE 218 FASTCPDDEE228 IELAYEQVAK238 ALK
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| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution
of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects
(Nat Rev Drug Discov, 20: 64-81, 2021).
Human Similarity Proteins
Human Tissue Distribution
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There is no similarity protein (E value < 0.005) for this target
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Note:
If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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| References | Top | |||||
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| REF 1 | Identification and Characterization of a Bacterial Homolog of Chloride Intracellular Channel (CLIC) Protein. Sci Rep. 2017 Aug 17;7(1):8500. | |||||
| REF 2 | Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution. J Biol Chem. 2001 Nov 30;276(48):44993-5000. | |||||
| REF 3 | Human CLIC1 in complex with NSC602247 | |||||
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