Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99092 | Target Info | |||
| Target Name | Chloride intracellular channel protein 1 (CLIC1) | ||||
| Synonyms | hRNCC; Regulatory nuclear chloride ion channel protein; Nuclear chloride ion channel 27; NCC27; G6; Chloride channel ABP | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | CLIC1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Glutathione | Ligand Info | |||||
| Structure Description | Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione | PDB:1K0N | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
PQVELFVKAG
15 SDGAKIGNCP25 FSQRLFMVLW35 LKGVTFNVTT45 VDTKRRTETV55 QKLCPGGELP 65 FLLYGTEVHT75 DTNKIEEFLE85 AVLCPPRYPK95 LAALNPESNT105 AGLDIFAKFS 115 AYIKNSNPAL125 NDNLEKGLLK135 ALKVLDNYLT145 SPLPEGVSQR165 KFLDGNELTL 175 ADCNLLPKLH185 IVQVVCKKYR195 GFTIPEAFRG205 VHRYLSNAYA215 REEFASTCPD 225 DEEIELAYEQ235 VAKALK
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| Ligand Name: 3-Sulfinoalanine | Ligand Info | |||||
| Structure Description | Human CLIC1 in complex with NSC602247 | PDB:7FBQ | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [2] |
| PDB Sequence |
QPQVELFVKA
14 GSDGAKIGNP25 FSQRLFMVLW35 LKGVTFNVTT45 VDTKRRTETV55 QKLCPGGQLP 65 FLLYGTEVHT75 DTNKIEEFLE85 AVLCPPRYPK95 LAALNPESNT105 AGLDIFAKFS 115 AYIKNSNPAL125 NDNLEKGLLK135 ALKVLDNYLT145 SPLPEEVDEE158 DEGVSQRKFL 168 DGNELTLADC178 NLLPKLHIVQ188 VVCKKYRGFT198 IPEAFRGVHR208 YLSNAYAREE 218 FASTCPDDEE228 IELAYEQVAK238 ALK
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| Ligand Name: 4-[[2-[(4-Hydroxyphenyl)amino]-6-methyl-pyrimidin-4-yl]amino]phenol | Ligand Info | |||||
| Structure Description | Human CLIC1 in complex with NSC602247 | PDB:7FBQ | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [2] |
| PDB Sequence |
QPQVELFVKA
14 GSDGAKIGNP25 FSQRLFMVLW35 LKGVTFNVTT45 VDTKRRTETV55 QKLCPGGQLP 65 FLLYGTEVHT75 DTNKIEEFLE85 AVLCPPRYPK95 LAALNPESNT105 AGLDIFAKFS 115 AYIKNSNPAL125 NDNLEKGLLK135 ALKVLDNYLT145 SPLPEEVDEE158 DEGVSQRKFL 168 DGNELTLADC178 NLLPKLHIVQ188 VVCKKYRGFT198 IPEAFRGVHR208 YLSNAYAREE 218 FASTCPDDEE228 IELAYEQVAK238 ALK
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution. J Biol Chem. 2001 Nov 30;276(48):44993-5000. | ||||
| REF 2 | Human CLIC1 in complex with NSC602247 | ||||
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