Target Information

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Target General Information
Different Human System Profiles of Target
Target Regulators
References
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
Protein Name Pfam ID Percentage of Identity (%) E value
RING finger protein 141 (RNF141)
PF13920
38.776 (19/49) 4.15E-04
E3 ubiquitin-protein ligase Topors (TOPORS)
PF13920
28.889 (13/45) 5.08E-04
Tripartite motif-containing protein 2 (TRIM2)
PF00630 ; 
PF01436 ; 
PF00643 ; 
PF13445
More >>
 36.170 (17/47) 1.00E-03
Tripartite motif-containing protein 3 (TRIM3)
PF00630 ; 
PF01436 ; 
PF00643 ; 
PF13445
More >>
 34.043 (16/47) 2.00E-03
RING finger protein 151 (RNF151)
PF13923
43.478 (20/46) 2.00E-03
E3 ubiquitin-protein ligase RBX1 (RBX1)
PF12678
54.545 (12/22) 3.00E-03
E3 ubiquitin-protein ligase RNF8 (RNF8)
PF00498 ; 
PF13920
31.111 (14/45) 3.00E-03
Anaphase-promoting complex subunit 11 (ANAPC11)
PF12861
50.000 (14/28) 3.00E-03
RING finger protein 214 (RNF214) 29.268 (24/82) 3.00E-03
E3 ubiquitin-protein ligase RNF25 (RNF25)
PF05773
20.833 (15/72) 5.00E-03
ORC ubiquitin ligase 1 (OBI1)
PF13923
39.583 (19/48) 5.00E-03
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