Target Information
Target General Information | Top | |||||
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Target ID |
T84894
(Former ID: TTDI03085)
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Target Name |
Casein kinase II (CSNK2)
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Gene Name |
NO-GeName
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Target Type |
Clinical trial target
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[1] | ||||
Disease | [+] 1 Target-related Diseases | + | ||||
1 | Cervical cancer [ICD-11: 2C77] | |||||
UniProt ID |
Drugs and Modes of Action | Top | |||||
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Clinical Trial Drug(s) | [+] 2 Clinical Trial Drugs | + | ||||
1 | CIGB-300 | Drug Info | Phase 3 | Cervical cancer | [1] | |
2 | CX-4945 | Drug Info | Phase 2 | Coronavirus infection | [2] | |
Mode of Action | [+] 2 Modes of Action | + | ||||
Modulator | [+] 2 Modulator drugs | + | ||||
1 | CIGB-300 | Drug Info | [1] | |||
2 | CX-4945 | Drug Info | [3] | |||
Inhibitor | [+] 1 Inhibitor drugs | + | ||||
1 | Tetrabromocinnamic acid | Drug Info | [4] |
Co-Targets | Top | |||||
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Co-Targets |
References | Top | |||||
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REF 1 | Synergistic interactions of the anti-casein kinase 2 CIGB-300 peptide and chemotherapeutic agents in lung and cervical preclinical cancer models. Mol Clin Oncol. 2014 Nov;2(6):935-944. | |||||
REF 2 | ClinicalTrials.gov (NCT04668209) Silmitasertib (CX-4945) in Patients With Severe Coronavirus Disease 2019 (COVID-19) (CX4945). U.S. National Institutes of Health. | |||||
REF 3 | CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathway. Leukemia. 2013 Oct;27(10):2094-6. | |||||
REF 4 | Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors. Chembiochem. 2007 Jan 2;8(1):129-39. |
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