Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T75907
(Former ID: TTDI01822)
|
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| Target Name |
ATP synthase (ATPS)
|
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| Gene Name |
NO-GeName
|
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| Target Type |
Literature-reported target
|
[1] | ||||
| Disease | [+] 1 Target-related Diseases | + | ||||
| 1 | Alzheimer disease [ICD-11: 8A20] | |||||
| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Clinical Trial Drug(s) | [+] 1 Clinical Trial Drugs | + | ||||
| 1 | J147 | Drug Info | Phase 1 | Alzheimer disease | [2] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| inhibitor | [+] 1 inhibitor drugs | + | ||||
| 1 | J147 | Drug Info | [3] | |||
| Chemical Structure based Activity Landscape of Target | Top |
|---|---|
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Research on relevance between mitochondrial ATP synthase and malignant tumor. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2014 Jun;31(3):714-7. | |||||
| REF 2 | ClinicalTrials.gov (NCT03838185) A Phase I, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Tolerability and Pharmacokinetics of Single Ascending Oral Doses of J147 in Healthy Young Volunteers and Healthy Elderly Volunteers. U.S.National Institutes of Health. | |||||
| REF 3 | Broadening the horizon: Integrative pharmacophore-based and cheminformatics screening of novel chemical modulators of mitochondria ATP synthase towards interventive Alzheimer's disease therapy. Med Hypotheses. 2019 Sep;130:109277. | |||||
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