Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T75440
(Former ID: TTDS00454)
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| Target Name |
Translocator protein (TSPO)
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| Synonyms |
Peripheral-type benzodiazepine receptor; Peripheral benzodiazepine receptor; PKBS; PBR; Mitochondrial benzodiazepine receptor; MBR; BZRP
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| Gene Name |
TSPO
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| Target Type |
Successful target
|
[1] | ||||
| Disease | [+] 6 Target-related Diseases | + | ||||
| 1 | Anxiety disorder [ICD-11: 6B00-6B0Z] | |||||
| 2 | Epilepsy/seizure [ICD-11: 8A61-8A6Z] | |||||
| 3 | Insomnia [ICD-11: 7A00-7A0Z] | |||||
| 4 | Intentional self-harm [ICD-11: PC91] | |||||
| 5 | Mood/affect symptom [ICD-11: MB24] | |||||
| 6 | Tonus and reflex abnormality [ICD-11: MB47] | |||||
| Function |
Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme.
Click to Show/Hide
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| BioChemical Class |
Cholesterol/porphyrin uptake translocator
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| UniProt ID | ||||||
| Sequence |
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAM
GYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAA ATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | AlphaFold | ||||
| ADReCS ID | BADD_A00167 ; BADD_A00264 ; BADD_A03955 ; BADD_A05517 | |||||
| HIT2.0 ID | T67U3B | |||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Approved Drug(s) | [+] 23 Approved Drugs | + | ||||
| 1 | Adinazolam | Drug Info | Approved | Anxiety disorder | [2] | |
| 2 | Alpidem | Drug Info | Approved | Anxiety disorder | [3] | |
| 3 | Alprazolam | Drug Info | Approved | Anxiety disorder | [4], [5] | |
| 4 | Chlordiazepoxide | Drug Info | Approved | Anxiety disorder | [6], [7] | |
| 5 | Chlormezanone | Drug Info | Approved | Anxiety disorder | [3], [8], [9] | |
| 6 | Cinolazepam | Drug Info | Approved | Muscle spasm | [10] | |
| 7 | Clorazepate | Drug Info | Approved | Anxiety disorder | [11], [12] | |
| 8 | Clotiazepam | Drug Info | Approved | Anxiety disorder | [13] | |
| 9 | Diazepam | Drug Info | Approved | Epilepsy | [14], [15] | |
| 10 | Estazolam | Drug Info | Approved | Insomnia | [16], [17] | |
| 11 | Eszopiclone | Drug Info | Approved | Insomnia | [18], [19] | |
| 12 | Fludiazepam | Drug Info | Approved | Anxiety disorder | [20] | |
| 13 | Flumazenil | Drug Info | Approved | Benzodiazepine overdose | [21], [22] | |
| 14 | Flunitrazepam | Drug Info | Approved | Insomnia | [23], [24] | |
| 15 | Flurazepam | Drug Info | Approved | Insomnia | [25], [26] | |
| 16 | Halazepam | Drug Info | Approved | Anxiety disorder | [27], [28] | |
| 17 | Lorazepam | Drug Info | Approved | Anxiety disorder | [29], [30] | |
| 18 | Midazolam | Drug Info | Approved | Irritability | [31], [32] | |
| 19 | Oxazepam | Drug Info | Approved | Anxiety disorder | [33], [34] | |
| 20 | Prazepam | Drug Info | Approved | Anxiety disorder | [35], [36] | |
| 21 | Quazepam | Drug Info | Approved | Insomnia | [37], [38] | |
| 22 | Temazepam | Drug Info | Approved | Insomnia | [39], [40] | |
| 23 | Triazolam | Drug Info | Approved | Insomnia | [41], [34] | |
| Clinical Trial Drug(s) | [+] 7 Clinical Trial Drugs | + | ||||
| 1 | 11C-PBR-28 | Drug Info | Phase 2 | Brain disease | [42] | |
| 2 | Dextofisopam | Drug Info | Phase 2 | Irritable bowel syndrome | [43] | |
| 3 | ONO-2952 | Drug Info | Phase 2 | Irritable bowel syndrome | [44] | |
| 4 | SSR-180575 | Drug Info | Phase 2 | Rheumatoid arthritis | [45] | |
| 5 | TLN-4601 | Drug Info | Phase 2 | Solid tumour/cancer | [46] | |
| 6 | 18F-FEDAA-1106 | Drug Info | Phase 1 | Alzheimer disease | [47] | |
| 7 | BAY-85-8102 | Drug Info | Phase 1 | Brain disease | [48] | |
| Discontinued Drug(s) | [+] 10 Discontinued Drugs | + | ||||
| 1 | Ro-16-6028 | Drug Info | Discontinued in Phase 3 | Anxiety disorder | [49], [50] | |
| 2 | Emapunil | Drug Info | Discontinued in Phase 2 | Anxiety disorder | [51], [52] | |
| 3 | Lirequinil | Drug Info | Discontinued in Phase 2 | Anxiety disorder | [53] | |
| 4 | S-8510 | Drug Info | Discontinued in Phase 2 | Cognitive impairment | [54] | |
| 5 | TRO-40303 | Drug Info | Discontinued in Phase 2 | Lateral sclerosis | [55] | |
| 6 | Imepitoin | Drug Info | Discontinued in Phase 1 | Convulsion | [56] | |
| 7 | DAA-1097 | Drug Info | Terminated | Anxiety disorder | [57] | |
| 8 | Miltirone | Drug Info | Terminated | Anxiety disorder | [58] | |
| 9 | NNC-13-8119 | Drug Info | Terminated | Anxiety disorder | [59] | |
| 10 | NS-2979 | Drug Info | Terminated | Pain | [60] | |
| Mode of Action | [+] 7 Modes of Action | + | ||||
| Agonist | [+] 18 Agonist drugs | + | ||||
| 1 | Adinazolam | Drug Info | [61] | |||
| 2 | Alprazolam | Drug Info | [1], [63] | |||
| 3 | Chlormezanone | Drug Info | [65] | |||
| 4 | Clotiazepam | Drug Info | [67] | |||
| 5 | Diazepam | Drug Info | [68], [69] | |||
| 6 | Estazolam | Drug Info | [70], [71] | |||
| 7 | Eszopiclone | Drug Info | [63], [72] | |||
| 8 | Fludiazepam | Drug Info | [73] | |||
| 9 | Flunitrazepam | Drug Info | [1] | |||
| 10 | Oxazepam | Drug Info | [75] | |||
| 11 | Dextofisopam | Drug Info | [43] | |||
| 12 | BAY-85-8102 | Drug Info | [74] | |||
| 13 | Emapunil | Drug Info | [84] | |||
| 14 | Lirequinil | Drug Info | [85] | |||
| 15 | S-8510 | Drug Info | [3] | |||
| 16 | Imepitoin | Drug Info | [87] | |||
| 17 | DAA-1097 | Drug Info | [88] | |||
| 18 | Benzodiazepine | Drug Info | [74] | |||
| Inhibitor | [+] 12 Inhibitor drugs | + | ||||
| 1 | Alpidem | Drug Info | [62] | |||
| 2 | SSR-180575 | Drug Info | [3], [78] | |||
| 3 | (R)PK-11195 | Drug Info | [93] | |||
| 4 | 2-(2-Phenyl-1H-indol-3-yl)-N,N-dipropyl-acetamide | Drug Info | [94] | |||
| 5 | 4-Methoxy-5-phenyl-6-thia-10b-aza-benzo[e]azulene | Drug Info | [95] | |||
| 6 | 5-Phenyl-6-thia-10b-aza-benzo[e]azulen-4-one | Drug Info | [96] | |||
| 7 | 5-Phenyl-6-thia-10b-aza-benzo[e]azulene | Drug Info | [95] | |||
| 8 | 6-Thia-10b-aza-benzo[e]azulen-4-one | Drug Info | [96] | |||
| 9 | N,N-Diethyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info | [94] | |||
| 10 | N,N-Dihexyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info | [94] | |||
| 11 | N,N-Dimethyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info | [94] | |||
| 12 | N-Hexyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info | [94] | |||
| Modulator | [+] 18 Modulator drugs | + | ||||
| 1 | Chlordiazepoxide | Drug Info | [64] | |||
| 2 | Clorazepate | Drug Info | [64] | |||
| 3 | Flurazepam | Drug Info | [64] | |||
| 4 | Halazepam | Drug Info | [64] | |||
| 5 | Lorazepam | Drug Info | [64] | |||
| 6 | Midazolam | Drug Info | [64] | |||
| 7 | Prazepam | Drug Info | [64] | |||
| 8 | Quazepam | Drug Info | [64] | |||
| 9 | Temazepam | Drug Info | [64] | |||
| 10 | Triazolam | Drug Info | [64] | |||
| 11 | TLN-4601 | Drug Info | [79] | |||
| 12 | 18F-FEDAA-1106 | Drug Info | [80] | |||
| 13 | Ro-16-6028 | Drug Info | [83] | |||
| 14 | TRO-40303 | Drug Info | [86] | |||
| 15 | Miltirone | Drug Info | [90] | |||
| 16 | NNC-13-8119 | Drug Info | [91] | |||
| 17 | NS-2979 | Drug Info | [92] | |||
| 18 | U-89854 | Drug Info | [74] | |||
| Binder | [+] 7 Binder drugs | + | ||||
| 1 | Cinolazepam | Drug Info | [66] | |||
| 2 | 11C-PBR-28 | Drug Info | [76] | |||
| 3 | 11C-PBR-170 | Drug Info | [74] | |||
| 4 | FGIN-1-27 | Drug Info | [97] | |||
| 5 | PK 11195 | Drug Info | [97] | |||
| 6 | Ro 5-4864 | Drug Info | [97], [98] | |||
| 7 | TGSC01AA(4) | Drug Info | [74] | |||
| Antagonist | [+] 2 Antagonist drugs | + | ||||
| 1 | Flumazenil | Drug Info | [74] | |||
| 2 | ONO-2952 | Drug Info | [77] | |||
| Ligand | [+] 93 Ligand drugs | + | ||||
| 1 | Aryl oxyanilide derivative 1 | Drug Info | [81] | |||
| 2 | Aryl oxyanilide derivative 2 | Drug Info | [81] | |||
| 3 | Aryl oxyanilide derivative 3 | Drug Info | [81] | |||
| 4 | Benzimidazolone acetamide derivative 1 | Drug Info | [81] | |||
| 5 | Benzimidazolone acetamide derivative 2 | Drug Info | [81] | |||
| 6 | Benzodiazepine derivative 1 | Drug Info | [81] | |||
| 7 | Benzothiazepine analog 1 | Drug Info | [81] | |||
| 8 | Benzothiazepine analog 2 | Drug Info | [81] | |||
| 9 | Benzothiazepine analog 3 | Drug Info | [81] | |||
| 10 | Benzothiazepine analog 4 | Drug Info | [81] | |||
| 11 | Benzothiazepine analog 5 | Drug Info | [81] | |||
| 12 | Benzothiazepine analog 6 | Drug Info | [81] | |||
| 13 | Benzothiazepine analog 7 | Drug Info | [81] | |||
| 14 | Benzothiazepine analog 8 | Drug Info | [81] | |||
| 15 | Benzothiazepine analog 9 | Drug Info | [81] | |||
| 16 | Benzoxazepine analog 1 | Drug Info | [81] | |||
| 17 | Bidentate pyrazolopyrimidine acetamide analog 1 | Drug Info | [81] | |||
| 18 | Bidentate pyrazolopyrimidine acetamide analog 2 | Drug Info | [81] | |||
| 19 | Bidentate pyrazolopyrimidine acetamide analog 3 | Drug Info | [81] | |||
| 20 | Bidentate pyrazolopyrimidine acetamide analog 4 | Drug Info | [81] | |||
| 21 | Imidazopyridine acetamide analog 1 | Drug Info | [81] | |||
| 22 | Imidazopyridine acetamide analog 2 | Drug Info | [81] | |||
| 23 | Imidazopyridine acetamide analog 3 | Drug Info | [81] | |||
| 24 | Imidazopyridine acetamide analog 4 | Drug Info | [81] | |||
| 25 | Imidazopyridine acetamide analog 5 | Drug Info | [81] | |||
| 26 | Imidazopyridine acetamide analog 6 | Drug Info | [81] | |||
| 27 | Imidazopyridine acetamide analog 7 | Drug Info | [81] | |||
| 28 | Imidazopyridine derivative 1 | Drug Info | [81] | |||
| 29 | Imidazopyridine derivative 2 | Drug Info | [81] | |||
| 30 | Imidazo[1,2-b]pyridazine acetamide derivative 1 | Drug Info | [81] | |||
| 31 | Imidazo[1,2-b]pyridazine acetamide derivative 2 | Drug Info | [81] | |||
| 32 | Imidazo[1,2-b]pyridazine acetamide derivative 3 | Drug Info | [81] | |||
| 33 | Imidazo[1,2-b]pyridazine acetamide derivative 4 | Drug Info | [81] | |||
| 34 | Imidazo[1,2-b]pyridazine acetamide derivative 5 | Drug Info | [81] | |||
| 35 | Imidazo[1,2-b]pyridazine acetamide derivative 6 | Drug Info | [81] | |||
| 36 | Imidazo[1,2-b]pyridazine acetamide derivative 7 | Drug Info | [81] | |||
| 37 | Indole-based analog 10 | Drug Info | [82] | |||
| 38 | Indole-based analog 5 | Drug Info | [82] | |||
| 39 | Indole-based analog 9 | Drug Info | [82] | |||
| 40 | Iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivative 1 | Drug Info | [81] | |||
| 41 | Iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivative 2 | Drug Info | [81] | |||
| 42 | Iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivative 3 | Drug Info | [81] | |||
| 43 | Isoquinoline carboxamide derivative 1 | Drug Info | [81] | |||
| 44 | Phenylpurine acetamide analog 1 | Drug Info | [81] | |||
| 45 | Phenylpurine acetamide analog 2 | Drug Info | [81] | |||
| 46 | PMID27599163-Compound-52 | Drug Info | [82] | |||
| 47 | PMID27599163-Compound-75 | Drug Info | [82] | |||
| 48 | PMID27599163-Compound-76 | Drug Info | [82] | |||
| 49 | PMID27599163-Compound-77 | Drug Info | [82] | |||
| 50 | PMID27599163-Compound-78 | Drug Info | [82] | |||
| 51 | PMID27599163-Compound-79 | Drug Info | [82] | |||
| 52 | PMID27599163-Compound-81 | Drug Info | [82] | |||
| 53 | PMID27599163-Compound-82 | Drug Info | [82] | |||
| 54 | PMID27607364-Compound-10 | Drug Info | [81] | |||
| 55 | PMID27607364-Compound-141 | Drug Info | [81] | |||
| 56 | PMID27607364-Compound-162 | Drug Info | [81] | |||
| 57 | PMID27607364-Compound-4 | Drug Info | [81] | |||
| 58 | PMID27607364-Compound-58 | Drug Info | [81] | |||
| 59 | PMID27607364-Compound-59 | Drug Info | [81] | |||
| 60 | PMID27607364-Compound-60 | Drug Info | [81] | |||
| 61 | PMID27607364-Compound-61 | Drug Info | [81] | |||
| 62 | PMID27607364-Compound-62 | Drug Info | [81] | |||
| 63 | PMID27607364-Compound-63 | Drug Info | [81] | |||
| 64 | PMID27607364-Compound-64 | Drug Info | [81] | |||
| 65 | PMID27607364-Compound-65 | Drug Info | [81] | |||
| 66 | Pyrazolopyrimidine acetamide analog 1 | Drug Info | [81] | |||
| 67 | Pyrazolopyrimidine acetamide analog 2 | Drug Info | [81] | |||
| 68 | Quinazoline derivative 2 | Drug Info | [81] | |||
| 69 | Quinazoline derivative 3 | Drug Info | [81] | |||
| 70 | Quinazoline derivative 4 | Drug Info | [81] | |||
| 71 | Quinazoline derivative 5 | Drug Info | [81] | |||
| 72 | Quinazoline derivative 6 | Drug Info | [81] | |||
| 73 | Quinazoline derivative 7 | Drug Info | [81] | |||
| 74 | Quinoline carboxamide derivative 10 | Drug Info | [81] | |||
| 75 | Quinoline carboxamide derivative 4 | Drug Info | [81] | |||
| 76 | Quinoline carboxamide derivative 5 | Drug Info | [81] | |||
| 77 | Quinoline carboxamide derivative 6 | Drug Info | [81] | |||
| 78 | Quinoline carboxamide derivative 7 | Drug Info | [81] | |||
| 79 | Quinoline carboxamide derivative 8 | Drug Info | [81] | |||
| 80 | Quinoline carboxamide derivative 9 | Drug Info | [81] | |||
| 81 | Tricyclic indole compound 1 | Drug Info | [82] | |||
| 82 | Tricyclic indole compound 10 | Drug Info | [82] | |||
| 83 | Tricyclic indole compound 11 | Drug Info | [82] | |||
| 84 | Tricyclic indole compound 12 | Drug Info | [82] | |||
| 85 | Tricyclic indole compound 14 | Drug Info | [82] | |||
| 86 | Tricyclic indole compound 2 | Drug Info | [82] | |||
| 87 | Tricyclic indole compound 3 | Drug Info | [82] | |||
| 88 | Tricyclic indole compound 4 | Drug Info | [82] | |||
| 89 | Tricyclic indole compound 5 | Drug Info | [82] | |||
| 90 | Tricyclic indole compound 6 | Drug Info | [82] | |||
| 91 | Tricyclic indole compound 7 | Drug Info | [82] | |||
| 92 | Tricyclic indole compound 8 | Drug Info | [82] | |||
| 93 | Tricyclic indole compound 9 | Drug Info | [82] | |||
| Suppressor | [+] 1 Suppressor drugs | + | ||||
| 1 | Ginkgolide B (GKB) | Drug Info | [89] | |||
| Chemical Structure based Activity Landscape of Target | Top |
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| Drug Property Profile of Target | Top | |
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| (1) Molecular Weight (mw) based Drug Clustering | (2) Octanol/Water Partition Coefficient (xlogp) based Drug Clustering | |
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| (3) Hydrogen Bond Donor Count (hbonddonor) based Drug Clustering | (4) Hydrogen Bond Acceptor Count (hbondacc) based Drug Clustering | |
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| (5) Rotatable Bond Count (rotbonds) based Drug Clustering | (6) Topological Polar Surface Area (polararea) based Drug Clustering | |
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| "RO5" indicates the cutoff set by lipinski's rule of five; "D123AB" colored in GREEN denotes the no violation of any cutoff in lipinski's rule of five; "D123AB" colored in PURPLE refers to the violation of only one cutoff in lipinski's rule of five; "D123AB" colored in BLACK represents the violation of more than one cutoffs in lipinski's rule of five | ||
| Co-Targets | Top | |||||
|---|---|---|---|---|---|---|
| Co-Targets | ||||||
| Target Poor or Non Binders | Top | |||||
|---|---|---|---|---|---|---|
| Target Poor or Non Binders | ||||||
| Target Profiles in Patients | Top | |||||
|---|---|---|---|---|---|---|
| Target Expression Profile (TEP) | ||||||
| Target Affiliated Biological Pathways | Top | |||||
|---|---|---|---|---|---|---|
| KEGG Pathway | [+] 2 KEGG Pathways | + | ||||
| 1 | Neuroactive ligand-receptor interaction | |||||
| 2 | HTLV-I infection | |||||
| Target-Related Models and Studies | Top | |||||
|---|---|---|---|---|---|---|
| Target Validation | ||||||
| Target QSAR Model | ||||||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation. J Pharmacol Sci. 2009 May;110(1):36-46. | |||||
| REF 2 | Drug information of Adinazolam, 2008. eduDrugs. | |||||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||||
| REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7111). | |||||
| REF 5 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074046. | |||||
| REF 6 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3370). | |||||
| REF 7 | Use of the accelerating rotarod for assessment of motor performance decrement induced by potential anticonvulsant compounds in nerve agent poisoning. Drug Chem Toxicol. 1992;15(3):177-201. | |||||
| REF 8 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7323). | |||||
| REF 9 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011467. | |||||
| REF 10 | Drug information of Cinolazepam, 2008. eduDrugs. | |||||
| REF 11 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7548). | |||||
| REF 12 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 071852. | |||||
| REF 13 | Drug information of Clotiazepam, 2008. eduDrugs. | |||||
| REF 14 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3364). | |||||
| REF 15 | ClinicalTrials.gov (NCT01939093) Therapeutic Effect of Quetiapine on Methamphetamine-Induced Psychosis. U.S. National Institutes of Health. | |||||
| REF 16 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7550). | |||||
| REF 17 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074818. | |||||
| REF 18 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7429). | |||||
| REF 19 | Emerging therapies for fibromyalgia. Expert Opin Emerg Drugs. 2008 Mar;13(1):53-62. | |||||
| REF 20 | Drug information of Fludiazepam, 2008. eduDrugs. | |||||
| REF 21 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4192). | |||||
| REF 22 | ClinicalTrials.gov (NCT00997087) A Randomized, Double-Blind, Placebo-Controlled Trial of Flumazenil for the Treatment of Obsessive Compulsive Disorder. U.S. National Institutes of Health. | |||||
| REF 23 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4360). | |||||
| REF 24 | Drug information of Flunitrazepam, 2008. eduDrugs. | |||||
| REF 25 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7188). | |||||
| REF 26 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 070344. | |||||
| REF 27 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7195). | |||||
| REF 28 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017736. | |||||
| REF 29 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5884). | |||||
| REF 30 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 071117. | |||||
| REF 31 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3342). | |||||
| REF 32 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 075154. | |||||
| REF 33 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7253). | |||||
| REF 34 | What every dentist should know about the "z-sedatives". J Mass Dent Soc. 2007 Fall;56(3):44-5. | |||||
| REF 35 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7275). | |||||
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