Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0VN4K
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| Former ID |
DNC001129
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| Drug Name |
PK 11195
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| Synonyms |
1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide; 85532-75-8; PK-11195; PK11195; RP 52028; BRN 4264456; CHEBI:73290; N-sec-butyl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide; N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide; N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide; 3-Isoquinolinecarboxamide, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-; SMR000058427; SR-01000076240; Biomol-NT_000287; AC1L1B9T; DSSTox_RID_79625; Interferon alfa (IFN-alpha)
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C21H21ClN2O
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| Canonical SMILES |
CCC(C)N(C)C(=O)C1=CC2=CC=CC=C2C(=N1)C3=CC=CC=C3Cl
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| InChI |
1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
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| InChIKey |
RAVIZVQZGXBOQO-UHFFFAOYSA-N
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| CAS Number |
CAS 85532-75-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5195352, 8151100, 11532932, 12015392, 14900970, 17404761, 24278822, 24439687, 26751834, 47440477, 47662507, 47810972, 47810973, 48035345, 49845849, 49845856, 49986420, 50104534, 50104535, 53777304, 53789464, 56312856, 57320876, 77248398, 85084791, 85230956, 85788339, 90340882, 91703379, 92303464, 103656034, 103858286, 104297470, 121360961, 124749535, 124800739, 124879541, 124879542, 124879543, 124879544, 125563859, 129102761, 134340126, 134340367, 134348755, 135089849, 135697515, 137148685, 142527063, 144210937
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| ChEBI ID |
CHEBI:73290
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| SuperDrug ATC ID |
R03DX06
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| SuperDrug CAS ID |
cas=112665437
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fibroblast growth factor receptor 2 (FGFR2) | Target Info | Binder | [1] |
| Translocator protein (TSPO) | Target Info | Binder | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| HTLV-I infection | ||||
| MAPK signaling pathway | ||||
| Ras signaling pathway | ||||
| Rap1 signaling pathway | ||||
| Endocytosis | ||||
| PI3K-Akt signaling pathway | ||||
| Signaling pathways regulating pluripotency of stem cells | ||||
| Regulation of actin cytoskeleton | ||||
| Pathways in cancer | ||||
| Prostate cancer | ||||
| Central carbon metabolism in cancer | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| Panther Pathway | FGF signaling pathway | |||
| Pathway Interaction Database | FGF signaling pathway | |||
| Reactome | Activated point mutants of FGFR2 | |||
| WikiPathways | Regulation of Actin Cytoskeleton | |||
| Ectoderm Differentiation | ||||
| Hair Follicle Development: Organogenesis (Part 2 of 3) | ||||
| Hair Follicle Development: Induction (Part 1 of 3) | ||||
| Cardiac Hypertrophic Response | ||||
| Signaling Pathways in Glioblastoma | ||||
| Neural Crest Differentiation | ||||
| Signaling by FGFR | ||||
| MicroRNAs in cardiomyocyte hypertrophy | ||||
| Angiogenesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. | |||
| REF 2 | Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br J Cancer. 2001 Nov 30;85(11):1771-80. | |||
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