Target Information
| Target General Information | Top | |||||
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| Target ID |
T62450
(Former ID: TTDR00592)
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| Target Name |
Candida Peptide N-myristoyltransferase (Candi NMT1)
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| Synonyms |
Peptide N-myristoyltransferase; NMT1; NMT; Myristoyl-CoA:protein N-myristoyltransferase
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| Gene Name |
Candi NMT1
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Substrate specificity requires an N- terminal glycine in the nascent polypeptide substrates. Ser is presentat position 5 in almost all known N-myristoyl proteins and Lys is commonly encountered at postion 6. Basic residues are preferred at positions 7 and 8.
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| BioChemical Class |
Acyltransferase
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| UniProt ID | ||||||
| EC Number |
EC 2.3.1.97
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| Sequence |
MSGDNTGNKSNSAPSKSIEELLKLLAMGQELSPAQQKEMKDYKFWKTQPVPSLSETVTEE
GPIDKLKTPEDVPNDPLPLISDFEWSTLDIDDNLQLDELYKLLYDNYVEDIDATFRFKYS HEFFQWALKPPGWRKDWHVGVRVKSTGKLVAFIAATPVTFKLNKSNKVIDSVEINFLCIH KKLRNKRLAPVLIKEITRRVNKQNIWQALYTGGSILPTPLTTCRYQHRPINWSKLHDVGF SHLPPNQTKSSMVASYTLPNNPKLKGLRPMTGKDVSTVLSLLYKYQERFDIVQLFTEEEF KHWMLGHDENSDSNVVKSYVVEDENGVITDYFSYYLLPFTVLDNAQHDELGIAYLFYYAS DSFEKPNYKKRLNELITDALITSKKFGVDVFNCLTCQDNTYFLKDCKFGSGDGFLNYYLF NYRTFPMDGGIDKKTKEVVEDQTSGIGVVLL Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: Myristoyl-Coa | Ligand Info | |||||
| Structure Description | Crystal structure of candida albicans N-myristoyltransferase with myristoyl-COA and peptidic inhibitor | PDB:1IYK | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [3] |
| PDB Sequence |
EGPIDKLKTP
69 EDVPNDPLPL79 ISDFEWSTLD89 IDDNLQLDEL99 YKLLYDNYVE109 DIDATFRFKY 119 SHEFFQWALK129 PPGWRKDWHV139 GVRVKSTGKL149 VAFIAATPVT159 FKLNKSNKVI 169 DSVEINFLCI179 HKKLRNKRLA189 PVLIKEITRR199 VNKQNIWQAL209 YTGGSILPTP 219 LTTCRYQHRP229 INWSKLHDVG239 FSHLPPNQTK249 SSMVASYTLP259 NNPKLKGLRP 269 MTGKDVSTVL279 SLLYKYQERF289 DIVQLFTEEE299 FKHWMLGHDE309 NSDSNVVKSY 319 VVEDENGIIT329 DYFSYYLLPF339 TVLDNAQHDE349 LGIAYLFYYA359 SDSFEKPNYK 369 KRLNELITDA379 LITSKKFGVD389 VFNCLTCQDN399 TYFLKDCKFG409 SGDGFLNYYL 419 FNYRTFPMDG429 GIDKKTKEVV439 EDQTSGIGVV449 LL
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ASN106
3.795
TYR107
3.671
VAL108
3.576
ILE153
4.917
VAL172
4.445
ILE174
3.784
ASN175
3.786
PHE176
3.500
LEU177
2.735
CYS178
3.527
ILE179
3.037
LEU183
4.358
ARG184
3.023
ASN185
2.802
LYS186
3.536
ARG187
2.817
LEU188
2.973
ALA189
2.934
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| Ligand Name: SC-58272 | Ligand Info | |||||
| Structure Description | Crystal structure of candida albicans N-myristoyltransferase with myristoyl-COA and peptidic inhibitor | PDB:1IYK | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [3] |
| PDB Sequence |
EGPIDKLKTP
69 EDVPNDPLPL79 ISDFEWSTLD89 IDDNLQLDEL99 YKLLYDNYVE109 DIDATFRFKY 119 SHEFFQWALK129 PPGWRKDWHV139 GVRVKSTGKL149 VAFIAATPVT159 FKLNKSNKVI 169 DSVEINFLCI179 HKKLRNKRLA189 PVLIKEITRR199 VNKQNIWQAL209 YTGGSILPTP 219 LTTCRYQHRP229 INWSKLHDVG239 FSHLPPNQTK249 SSMVASYTLP259 NNPKLKGLRP 269 MTGKDVSTVL279 SLLYKYQERF289 DIVQLFTEEE299 FKHWMLGHDE309 NSDSNVVKSY 319 VVEDENGIIT329 DYFSYYLLPF339 TVLDNAQHDE349 LGIAYLFYYA359 SDSFEKPNYK 369 KRLNELITDA379 LITSKKFGVD389 VFNCLTCQDN399 TYFLKDCKFG409 SGDGFLNYYL 419 FNYRTFPMDG429 GIDKKTKEVV439 EDQTSGIGVV449 LL
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TYR107
4.651
VAL108
3.378
GLU109
3.582
ASP110
2.626
ILE111
4.437
ASP112
3.232
THR114
4.483
PHE115
4.002
PHE117
3.486
TYR119
3.698
ASN175
3.320
THR211
3.089
GLY212
4.174
GLY213
4.185
TYR225
3.450
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| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
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There is no similarity protein (E value < 0.005) for this target
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| Chemical Structure based Activity Landscape of Target | Top |
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| Drug Property Profile of Target | Top | |
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| (1) Molecular Weight (mw) based Drug Clustering | (2) Octanol/Water Partition Coefficient (xlogp) based Drug Clustering | |
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| (3) Hydrogen Bond Donor Count (hbonddonor) based Drug Clustering | (4) Hydrogen Bond Acceptor Count (hbondacc) based Drug Clustering | |
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| (5) Rotatable Bond Count (rotbonds) based Drug Clustering | (6) Topological Polar Surface Area (polararea) based Drug Clustering | |
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| "RO5" indicates the cutoff set by lipinski's rule of five; "D123AB" colored in GREEN denotes the no violation of any cutoff in lipinski's rule of five; "D123AB" colored in PURPLE refers to the violation of only one cutoff in lipinski's rule of five; "D123AB" colored in BLACK represents the violation of more than one cutoffs in lipinski's rule of five | ||
| Target Poor or Non Binders | Top | |||||
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| Target Poor or Non Binders | ||||||
| Target-Related Models and Studies | Top | |||||
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| Target Validation | ||||||
| References | Top | |||||
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| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||||
| REF 2 | Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-... J Biol Chem. 2007 Jul 27;282(30):22185-94. | |||||
| REF 3 | Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors. Chem Biol. 2002 Oct;9(10):1119-28. | |||||
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