Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T62450 | Target Info | |||
| Target Name | Candida Peptide N-myristoyltransferase (Candi NMT1) | ||||
| Synonyms |
Peptide N-myristoyltransferase; NMT1; NMT; Myristoyl-CoA:protein N-myristoyltransferase
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| Target Type | Literature-reported Target | ||||
| Gene Name | Candi NMT1 | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ethyl 4-{2-[(tert-butyl)amino]ethoxy}-3-methylbenzo[d]furan-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL55282; SCHEMBL6874240; CTK6F7809; BDBM50218699; ethyl 4-[2-(tert-butylamino)ethoxy]-3-methyl-1-benzofuran-2-carboxylate; DB-129887; ethyl 4-(2-(tert-butylamino)ethoxy)-3-methylbenzofuran-2-carboxylate; ethyl 4-[2-(tert-butylamino)ethoxy]-3-methyl-benzofuran-2-carboxylate; 3-Methyl-4-[2-(tert-butylamino)ethoxy]-2-benzofurancarboxylic acid ethyl ester; 4-(2-tert-Butylamino-ethoxy)-3-methyl-benzofuran-2-carboxylic acid ethyl ester
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
Ethyl 4-[2-(pyridin-3-ylmethylamino)ethoxy]-1-benzofuran-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262497; BDBM50487480
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| Activity |
IC50 = 79000 nM
|
[1] | |||
| Compound Name |
(2S)-6-Amino-N-[(2S)-1-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-3-hydroxy-2-[[2-[[(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-4-methyl-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]propanoyl]-methylamino]acetyl]amino]propanoyl]amino]hexanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350017
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| Activity |
IC50 = 80000 nM
|
[2] | |||
| Compound Name |
Ethyl 3-propan-2-yl-4-[2-(pyridin-3-ylmethylamino)ethoxy]-1-benzofuran-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262496; BDBM50487477
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|
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| Activity |
IC50 = 83000 nM
|
[1] | |||
| Compound Name |
Methyl(2s)-2-[[(2s)-6-amino-2-[[(2s)-2-(7-aminoheptanoylamino)-3-hydroxy-propanoyl]amino]hexanoyl]amino]-4-methyl-pentanoate hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL539106; CTK7E7770; (AMINOHEPTANOYL)-SER-LYS-LEU-OMe, HYDROCHLORIDE
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-6-Amino-N-[(2S)-1-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-(3-aminopropanoylamino)-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]hexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350019
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|
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| Activity |
IC50 = 110000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 27 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
11-Amino-N-[(2R)-1-[[(2R)-6-amino-1-(3-methylbutylamino)-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]undecanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL33333; BDBM50057698
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| Activity |
IC50 = 365000 nM
|
[2] | |||
| Compound Name |
L-Leucinamide, N-(11-amino-1-oxoundecyl)-L-seryl-L-lysyl-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL34801; CTK0A9079; DTXSID60332738; BDBM50034991
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|
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
1-[1-[3-Methyl-4-[2-(pyridin-3-ylmethylamino)ethoxy]-1-benzofuran-2-yl]imidazol-2-yl]ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262498; BDBM50487476
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|
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| Activity |
IC50 = 1000000 nM
|
[1] | |||
| Compound Name |
2-[[2-[(2,3-Difluorophenoxy)methyl]-3-methyl-1-benzofuran-4-yl]oxy]-N-(pyridin-3-ylmethyl)ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262503; BDBM50487473
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|
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| Activity |
IC50 = 3700837.36 nM
|
[1] | |||
| Compound Name |
2-[[2-[(4-Fluorophenoxy)methyl]-3-methyl-1-benzofuran-4-yl]oxy]-N-(pyridin-3-ylmethyl)ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262507; BDBM50487471
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|
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| Activity |
IC50 = 5201157.44 nM
|
[1] | |||
| Compound Name |
2-[[3-Methyl-2-[(2,3,4-trifluorophenoxy)methyl]-1-benzofuran-4-yl]oxy]-N-(pyridin-3-ylmethyl)ethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262505; BDBM50487472
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|
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| Activity |
IC50 = 5700330.02 nM
|
[1] | |||
| Compound Name |
2-[[2-[(2,4-Difluorophenoxy)methyl]-3-methyl-1-benzofuran-4-yl]oxy]-N-(pyridin-3-ylmethyl)ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262506; BDBM50487484
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|
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| Activity |
IC50 = 7500668.99 nM
|
[1] | |||
| Compound Name |
2-[[2-[(2-Fluorophenoxy)methyl]-3-methyl-1-benzofuran-4-yl]oxy]-N-(pyridin-3-ylmethyl)ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262504; BDBM50487470
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|
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| Activity |
IC50 = 8300418.7 nM
|
[1] | |||
| Compound Name |
4-[[3-Methyl-4-[2-(pyridin-3-ylmethylamino)ethoxy]-1-benzofuran-2-yl]methoxy]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262509; BDBM50487483
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|
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| Activity |
IC50 = 9401561.69 nM
|
[1] | |||
| Compound Name |
2-[[3-Methyl-4-[2-(pyridin-3-ylmethylamino)ethoxy]-1-benzofuran-2-yl]methoxy]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262500; BDBM50487487
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|
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| Activity |
IC50 = 17001999.54 nM
|
[1] | |||
| Compound Name |
2-[[2-[5-(Methoxymethyl)-1-benzofuran-2-yl]-3-methyl-1-benzofuran-4-yl]oxy]-N-(pyridin-3-ylmethyl)ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262499; BDBM50487468
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|
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| Activity |
IC50 = 30005440.02 nM
|
[1] | |||
| Compound Name |
2-[[2-[(4-Chlorophenoxy)methyl]-3-methyl-1-benzofuran-4-yl]oxy]-N-(pyridin-3-ylmethyl)ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262508; BDBM50487467
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|
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| Activity |
IC50 = 43052661.05 nM
|
[1] | |||
| Compound Name |
Ethyl 4-[5-(tert-butylamino)pentoxy]-3-methyl-1-benzofuran-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL52854; Ethyl 4-{5-[(tert-butyl)amino]pentyloxy}-3-methylbenzo[d]furan-2-carboxylate; SCHEMBL3477347; CTK6F7801; BDBM50218694; DB-129900; ethyl 4-(5-(tert-butylamino)pentyloxy)-3-methylbenzofuran-2-carboxylate; ethyl 4-[5-(tert-butylamino)pentoxy]-3-methyl-benzofuran-2-carboxylate; 3-Methyl-4-[5-(tert-butylamino)pentoxy]-2-benzofurancarboxylic acid ethyl ester
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|
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| Activity |
IC50 = 66680676.92 nM
|
[1] | |||
| Compound Name |
2-[[3-Methyl-2-(phenoxymethyl)-1-benzofuran-4-yl]oxy]-N-(pyridin-3-ylmethyl)ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262501; BDBM50487475
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|
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| Activity |
IC50 = 72011192.02 nM
|
[1] | |||
| Compound Name |
Ethyl 3-ethyl-4-[2-(pyridin-3-ylmethylamino)ethoxy]-1-benzofuran-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262495; BDBM50487478
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|
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| Activity |
IC50 = 100000000 nM
|
[1] | |||
| Compound Name |
Ethyl 3-methyl-4-[2-(pyridin-3-ylmethylamino)ethoxy]-1-benzofuran-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262494; BDBM50487469
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|
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| Activity |
IC50 = 100000000 nM
|
[1] | |||
| Compound Name |
2-[[2-[(3-Fluorophenoxy)methyl]-3-methyl-1-benzofuran-4-yl]oxy]-N-(pyridin-3-ylmethyl)ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262502; BDBM50487474
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|
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| Activity |
IC50 = 110001852.8 nM
|
[1] | |||
| Compound Name |
Ethyl 3-cyclopropyl-4-[2-(pyridin-3-ylmethylamino)ethoxy]-1-benzofuran-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262492; BDBM50487486
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|
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| Activity |
IC50 = 227300295.3 nM
|
[1] | |||
| Compound Name |
Ethyl 4-{4-[(tert-butyl)amino]butoxy}-3-methylbenzo[d]furan-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL53246; SCHEMBL3471593; CTK6F7802; BDBM50218743; ethyl 4-[4-(tert-butylamino)butoxy]-3-methyl-1-benzofuran-2-carboxylate; DB-129894; ethyl 4-(4-(tert-butylamino)butoxy)-3-methylbenzofuran-2-carboxylate; ethyl 4-[4-(tert-butylamino)butoxy]-3-methyl-benzofuran-2-carboxylate; 3-Methyl-4-[4-(tert-butylamino)butoxy]-2-benzofurancarboxylic acid ethyl ester
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|
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| Activity |
IC50 = 227300295.3 nM
|
[1] | |||
| Compound Name |
Ethyl 4-[2-hydroxy-3-(isopropylamino)propoxy]-3-methyl-1-benzofuran-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL53849; MLS000039218; SMR000036354; Non peptidic, 1; Oprea1_405322; SCHEMBL6867852; BDBM96235; cid_6602742; CTK6F7799; STK526668; AKOS005459846; MCULE-4669012965; Ro-09-3472; DA-42923; FT-0739255; AH-262/32338079; ethyl 4-[2-hydroxy-3-(isopropylamino)propoxy]-3-methyl-benzofuran-2-carboxylate
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|
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| Activity |
IC50 = 227300295.3 nM
|
[1] | |||
| Compound Name |
Ethyl 4-[2-(benzylamino)ethoxy]-3-methyl-1-benzofuran-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262493; BDBM50487481
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|
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| Activity |
IC50 = 303040029.8 nM
|
[1] | |||
| Compound Name |
3-Methyl-N-phenyl-4-[2-(pyridin-3-ylmethylamino)ethoxy]-1-benzofuran-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262490; BDBM50487485
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|
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| Activity |
IC50 = 454569193.6 nM
|
[1] | |||
| Compound Name |
4-(3-Tert-Butylamino-propoxy)-3-methyl-benzofuran-2-carboxylic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL53935; Ethyl 4-{3-[(tert-butyl)amino]propoxy}-3-methylbenzo[d]furan-2-carboxylate; SCHEMBL6871813; CTK6F7803; ZINC6403601; BDBM50101968; ethyl 4-[3-(tert-butylamino)propoxy]-3-methyl-1-benzofuran-2-carboxylate; DA-42924; FT-0703325; ethyl 4-(3-(tert-butylamino)propoxy)-3-methylbenzofuran-2-carboxylate; ethyl 4-[3-(tert-butylamino)propoxy]-3-methyl-benzofuran-2-carboxylate; 3-Methyl-4-[3-(tert-butylamino)propoxy]-2-benzofurancarboxylic acid ethyl ester
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|
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| Activity |
IC50 = 588301560 nM
|
[1] | |||
| Compound Name |
2-[[3-Methyl-2-(phenylsulfanylmethyl)-1-benzofuran-4-yl]oxy]-N-(pyridin-3-ylmethyl)ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262491; BDBM50487479
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|
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| Activity |
IC50 = 620011864.2 nM
|
[1] | |||
| Compound Name |
Ethyl 3-methyl-4-[3-(1-piperidyl)propoxy]benzofuran-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL53026; BDBM50218690; DB-129892; 3-Methyl-4-(3-piperidinopropoxy)-2-benzofurancarboxylic acid ethyl ester; ethyl 4-(3-(piperidin-1-yl)propoxy)-3-methylbenzofuran-2-carboxylate
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| Activity |
IC50 = 625028758 nM
|
[1] | |||
| Compound Name |
Ethyl 4-{3-[(tert-butyl)amino]-2-hydroxypropoxy}-3-methylbenzo[d]furan-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL51667; CTK6F7798; BDBM50218691; 3-Methyl-4-[2-hydroxy-3-(tert-butylamino)propoxy]-2-benzofurancarboxylic acid ethyl ester; ethyl 4-[3-(tert-butylamino)-2-hydroxy-propoxy]-3-methyl-benzofuran-2-carboxylate
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|
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| Activity |
IC50 = 833297348.6 nM
|
[1] | |||
| Compound Name |
2-[[3-Methyl-2-(2-phenylethyl)-1-benzofuran-4-yl]oxy]-N-(pyridin-3-ylmethyl)ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262489; BDBM50487482
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|
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| Activity |
IC50 = 833489244.5 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | QSAR analysis of N-myristoyltransferase inhibitors: antifungal activity of benzofurans. Med Chem Res. 2008 Jul 29;18:206-20. | ||||
| REF 2 | Conformationally constrained [p-(omega-aminoalkyl)phenacetyl]-L-seryl-L-lysyl dipeptide amides as potent peptidomimetic inhibitors of Candida albicans and human myristoyl-CoA:protein N-myristoyl transferase. J Med Chem. 1997 May 9;40(10):1422-38. | ||||
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