Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T59735
(Former ID: TTDI01567)
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| Target Name |
Interferon receptor (IFNR)
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| Synonyms |
Interferon receptor
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| Gene Name |
NO-GeName
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| Target Type |
Clinical trial target
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[1] | ||||
| Disease | [+] 2 Target-related Diseases | + | ||||
| 1 | Hepatitis virus infection [ICD-11: 1E50-1E51] | |||||
| 2 | Human immunodeficiency virus disease [ICD-11: 1C60-1C62] | |||||
| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Clinical Trial Drug(s) | [+] 2 Clinical Trial Drugs | + | ||||
| 1 | HDV-interferon | Drug Info | Phase 2 | Hepatitis C virus infection | [2] | |
| 2 | Z-100 | Drug Info | Phase 1 | Human immunodeficiency virus infection | [3] | |
| Discontinued Drug(s) | [+] 2 Discontinued Drugs | + | ||||
| 1 | Bropirimine | Drug Info | Discontinued in Phase 3 | Virus infection | [4] | |
| 2 | Omniferon | Drug Info | Terminated | Solid tumour/cancer | [5] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Modulator | [+] 4 Modulator drugs | + | ||||
| 1 | HDV-interferon | Drug Info | [1] | |||
| 2 | Z-100 | Drug Info | [6], [7] | |||
| 3 | Bropirimine | Drug Info | [8] | |||
| 4 | Omniferon | Drug Info | [9] | |||
| Co-Targets | Top | |||||
|---|---|---|---|---|---|---|
| Co-Targets | ||||||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Interferon in HDV infection. Antiviral Res. 1994 Jul;24(2-3):165-74. | |||||
| REF 2 | ClinicalTrials.gov (NCT00703872) HDV-Interferon in the Treatment of Chronic Hepatitis C Nonresponders and Naive Hepatitis C Patients. U.S. National Institutes of Health. | |||||
| REF 3 | ClinicalTrials.gov (NCT00016692) Safety and Tolerability of Z-100 in Patients With Early HIV Infection. U.S. National Institutes of Health. | |||||
| REF 4 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000744) | |||||
| REF 5 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011081) | |||||
| REF 6 | Inhibition of human immunodeficiency virus type 1 replication by Z-100, an immunomodulator extracted from human-type tubercle bacilli, in macrophages. J Gen Virol. 2004 Sep;85(Pt 9):2603-13. | |||||
| REF 7 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||||
| REF 8 | Comparison between circulating interferon and drug levels following administration of 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP) to different animal species. J Interferon Res. 1982;2(3):317-27. | |||||
| REF 9 | US patent application no. 2004,0229,936, Treatment of hepatitis c virus infection with sesquiterpene lactones. | |||||
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