Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T59735 Target Info
Target Name Interferon receptor (IFNR)
Synonyms
Interferon receptor
    Click to Show/Hide
Target Type Clinical trial Target
Gene Name NO-GeName
UniProt ID
NOUNIPROTAC
Co-Targets of This Target  Top
Co-Target Name GABA(A) receptor alpha-1 (GABRA1) Successful Target
UniProt ID GBRA1_HUMAN
Gene Name GABRA1
Synonyms
Gamma-aminobutyric acid receptor subunit alpha-1; GABA(A) receptor subunit alpha-1
    Click to Show/Hide
Representative Drug(s) Z-100 Drug Info IC50 = 14 nM [1]
Co-Target Name GABA(A) receptor alpha-3 (GABRA3) Successful Target
UniProt ID GBRA3_HUMAN
Gene Name GABRA3
Synonyms
Gamma-aminobutyric acid receptor subunit alpha-3; GABA-A receptor alpha 3; GABA(A)Gamma-aminobutyric-acid receptor alpha-3 subunit precursor receptor; GABA(A) receptor subunit alpha-3
    Click to Show/Hide
Representative Drug(s) Z-100 Drug Info Ki = 400 nM [2]
Co-Target Name GABA(A) receptor alpha-2 (GABRA2) Successful Target
UniProt ID GBRA2_HUMAN
Gene Name GABRA2
Synonyms
GABRA2; GABA-A receptor alpha 2; GABA(A)Gamma-aminobutyric-acid receptor alpha-2 subunit precursor receptor
    Click to Show/Hide
Representative Drug(s) Z-100 Drug Info EC50 = 737 nM [3]
Co-Target Name GABA A receptor alpha-1/beta-2/gamma-2 (GABRA1/GABRB2/GABRG2) Co-Target
UniProt ID GBRA1_HUMAN-GBRB2_HUMAN-GBRG2_HUMAN
Gene Name GABRA1-GABRB2-GABRG2
Representative Drug(s) Z-100 Drug Info Ki = 26.7 nM Click to Show More [4]
2 Z-100 Drug Info Ki = 26.7 nM [4]
3 Z-100 Drug Info IC50 = 46.3 nM [1]
4 Z-100 Drug Info IC50 = 46.3 nM [1]
Co-Target Name GABA A receptor alpha-1/beta-1/gamma-2 (GABRA1/GABRB1/GABRG2) Co-Target
UniProt ID GBRA1_HUMAN-GBRB1_HUMAN-GBRG2_HUMAN
Gene Name GABRA1-GABRB1-GABRG2
Representative Drug(s) Z-100 Drug Info Ki = 53 nM [5]
Co-Target Name GABA A receptor alpha-2/beta-3/gamma-2 (GABRA2/GABRB3/GABRG2) Co-Target
UniProt ID GBRA2_HUMAN-GBRB3_HUMAN-GBRG2_HUMAN
Gene Name GABRA2-GABRB3-GABRG2
Representative Drug(s) Z-100 Drug Info Ki = 103 nM [6]
Co-Target Name GABA A receptor alpha-2/beta-2/gamma-2 (GABRA2/GABRB2/GABRG2) Co-Target
UniProt ID GBRA2_HUMAN-GBRB2_HUMAN-GBRG2_HUMAN
Gene Name GABRA2-GABRB2-GABRG2
Representative Drug(s) Z-100 Drug Info EC50 = 180 nM [7]
Co-Target Name GABA A receptor alpha-3/beta-3/gamma-2 (GABRA3/GABRB3/GABRG2) Co-Target
UniProt ID GBRA3_HUMAN-GBRB3_HUMAN-GBRG2_HUMAN
Gene Name GABRA3-GABRB3-GABRG2
Representative Drug(s) Z-100 Drug Info Ki = 246 nM [6]
Co-Target Name GABA A receptor alpha-3/beta-2/gamma-2 (GABRA3/GABRB2/GABRG2) Co-Target
UniProt ID GBRA3_HUMAN-GBRB2_HUMAN-GBRG2_HUMAN
Gene Name GABRA3-GABRB2-GABRG2
Representative Drug(s) Z-100 Drug Info Ki = 975 nM [8]
References  Top
REF 1 A conformational study of ligands for omega modulatory sites of GABAa receptors by NOESY NMR spectroscopy and distance geometry. Bioorg Med Chem Lett. 1997 Sep 9;7(17):2277-82.
REF 2 Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases. Eur J Med Chem. 2019 Nov 1;181:111569.
REF 3 Synthesis and biological evaluation of 7,8,9,10-tetrahydroimidazo[1,2-c]pyrido[3,4-e]pyrimdin-5(6H)-ones as functionally selective ligands of the benzodiazepine receptor site on the GABA(A) receptor. J Med Chem. 2002 Nov 7;45(23):5043-51.
REF 4 Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. J Med Chem. 2000 Jan 13;43(1):71-95.
REF 5 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33.
REF 6 Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA A receptor agonists at the alpha3 subunit. J Med Chem. 2005 Mar 10;48(5):1367-83.
REF 7 Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new se... J Med Chem. 1997 Sep 12;40(19):3109-18.
REF 8 Structural requirements for eszopiclone and zolpidem binding to the gamma-aminobutyric acid type-A (GABAA) receptor are different. J Med Chem. 2008 Nov 27;51(22):7243-52.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.