Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T55643
(Former ID: TTDI01415)
|
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| Target Name |
Heat shock protein (HSP)
|
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| Gene Name |
NO-GeName
|
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| Target Type |
Clinical trial target
|
[1] | ||||
| Disease | [+] 2 Target-related Diseases | + | ||||
| 1 | Cerebral ischaemia [ICD-11: 8B1Z] | |||||
| 2 | Idiopathic inflammatory myopathy [ICD-11: 4A41] | |||||
| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Clinical Trial Drug(s) | [+] 2 Clinical Trial Drugs | + | ||||
| 1 | Arimoclomol | Drug Info | Phase 2/3 | Cerebrovascular ischaemia | [2], [3] | |
| 2 | Heat shock protein vaccine | Drug Info | Phase 2 | Meningococcal infection | [4] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Modulator | [+] 1 Modulator drugs | + | ||||
| 1 | Arimoclomol | Drug Info | [5] | |||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Heat shock proteins (HSPs) based anti-cancer vaccines. Curr Mol Med. 2012 Nov 1;12(9):1183-97. | |||||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8271). | |||||
| REF 3 | ClinicalTrials.gov (NCT00706147) Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis. U.S. National Institutes of Health. | |||||
| REF 4 | Clinical pipeline report, company report or official report of Agenus. | |||||
| REF 5 | Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96. | |||||
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