Drug Information
Drug General Information | Top | |||
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Drug ID |
D0F2PD
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Former ID |
DIB011918
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Drug Name |
Arimoclomol
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Synonyms |
BRX-345
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Drug Type |
Small molecular drug
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Indication | Cerebrovascular ischaemia [ICD-11: 8B1Z; ICD-10: I67.8; ICD-9: 434.91] | Phase 2/3 | [1], [2] | |
Inclusion body myositis [ICD-11: 4A41.2; ICD-10: G72.8] | Phase 2/3 | [3] | ||
Company |
Biorex Research and Development Co
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Structure |
Download2D MOL |
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Formula |
C14H20ClN3O3
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Canonical SMILES |
C1CCN(CC1)CC(CON=C(C2=C[N+](=CC=C2)[O-])Cl)O
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InChI |
1S/C14H20ClN3O3/c15-14(12-5-4-8-18(20)9-12)16-21-11-13(19)10-17-6-2-1-3-7-17/h4-5,8-9,13,19H,1-3,6-7,10-11H2/b16-14-/t13-/m1/s1
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InChIKey |
SGEIEGAXKLMUIZ-XUVDNFPMSA-N
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CAS Number |
CAS 289893-25-0
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Heat shock protein (HSP) | Target Info | Modulator | [4] |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8271). | |||
REF 2 | ClinicalTrials.gov (NCT00706147) Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis. U.S. National Institutes of Health. | |||
REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
REF 4 | Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96. |
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