Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T30418
(Former ID: TTDI01179)
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| Target Name |
DNA synthesis (DNA synth)
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| Gene Name |
NO-GeName
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| Target Type |
Successful target
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[1] | ||||
| Disease | [+] 1 Target-related Diseases | + | ||||
| 1 | Leukaemia [ICD-11: 2A60-2B33] | |||||
| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Approved Drug(s) | [+] 1 Approved Drugs | + | ||||
| 1 | Nelarabine | Drug Info | Approved | leukaemia | [2], [3], [4], [5] | |
| Clinical Trial Drug(s) | [+] 4 Clinical Trial Drugs | + | ||||
| 1 | acelarin | Drug Info | Phase 3 | Biliary tract cancer | [6] | |
| 2 | Glufosfamide | Drug Info | Phase 3 | Pancreatic cancer | [1] | |
| 3 | FF-10502-01 | Drug Info | Phase 1 | Lymphoma | [1] | |
| 4 | TAR-200 | Drug Info | Phase 1 | Bladder cancer | [1] | |
| Discontinued Drug(s) | [+] 2 Discontinued Drugs | + | ||||
| 1 | CLOTURIN | Drug Info | Discontinued in Phase 2 | Solid tumour/cancer | [7] | |
| 2 | EPD-clofarabine | Drug Info | Terminated | Solid tumour/cancer | [8], [9] | |
| Mode of Action | [+] 3 Modes of Action | + | ||||
| Binder | [+] 1 Binder drugs | + | ||||
| 1 | Nelarabine | Drug Info | [5] | |||
| Inhibitor | [+] 5 Inhibitor drugs | + | ||||
| 1 | acelarin | Drug Info | [1] | |||
| 2 | Glufosfamide | Drug Info | [1] | |||
| 3 | FF-10502-01 | Drug Info | [1] | |||
| 4 | TAR-200 | Drug Info | [1] | |||
| 5 | EPD-clofarabine | Drug Info | [8], [9] | |||
| Modulator | [+] 1 Modulator drugs | + | ||||
| 1 | CLOTURIN | Drug Info | [8], [9], [10] | |||
| Drug Property Profile of Target | Top | |
|---|---|---|
| (1) Molecular Weight (mw) based Drug Clustering | (2) Octanol/Water Partition Coefficient (xlogp) based Drug Clustering | |
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| (3) Hydrogen Bond Donor Count (hbonddonor) based Drug Clustering | (4) Hydrogen Bond Acceptor Count (hbondacc) based Drug Clustering | |
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| (5) Rotatable Bond Count (rotbonds) based Drug Clustering | (6) Topological Polar Surface Area (polararea) based Drug Clustering | |
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| "RO5" indicates the cutoff set by lipinski's rule of five; "D123AB" colored in GREEN denotes the no violation of any cutoff in lipinski's rule of five; "D123AB" colored in PURPLE refers to the violation of only one cutoff in lipinski's rule of five; "D123AB" colored in BLACK represents the violation of more than one cutoffs in lipinski's rule of five | ||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7090). | |||||
| REF 3 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||||
| REF 4 | 2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006). | |||||
| REF 5 | Nelarabine. Drugs. 2008;68(4):439-47. | |||||
| REF 6 | ClinicalTrials.gov (NCT04163900) Comparing NUC-1031 Plus Cisplatin to Gemcitabine Plus Cisplatin in Patients With Advanced Biliary Tract Cancer. U.S. National Institutes of Health. | |||||
| REF 7 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002443) | |||||
| REF 8 | 2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4. | |||||
| REF 9 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||||
| REF 10 | Inhibition of biosynthetic processes in P388 and Ehrlich ascites cells by cloturin. Drugs Exp Clin Res. 1988;14(9):575-80. | |||||
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