Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0B8UJ
|
|||
Former ID |
DAP000985
|
|||
Drug Name |
Nelarabine
|
|||
Synonyms |
Arranon; ArranonG; Atriance; Nelzarabine; Nelarabine [USAN]; Nelzarabine [USAN]; GW 506U78; GW506U78; U78; Arranon (GlaxoSmithKline); Arranon (TN); Arranon, Nelarabine; Atriance (TN); GW-506U; GW-506U78; Nelarabine (INN); Nelzarabine (USAN); O-Methoxydeoxyguanosine; O-Methylguanosine; Nelarabine (JAN/USAN); (2R,3R,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3S,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (3S,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 2-(2-Amino-6-methoxy-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol; 2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 2-Amino-6-methoxypurine arabinoside; 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine; 6'-O-Methylguanosine; 9-beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine; 9beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | leukaemia [ICD-11: 2A60-2B33; ICD-9: 208.9] | Approved | [1], [2], [3], [4] | |
Therapeutic Class |
Anticancer Agents
|
|||
Company |
GlaxoSmithKline
|
|||
Structure |
Download2D MOL |
|||
Formula |
C11H15N5O5
|
|||
Canonical SMILES |
COC1=NC(=NC2=C1N=CN2C3C(C(C(O3)CO)O)O)N
|
|||
InChI |
1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1
|
|||
InChIKey |
IXOXBSCIXZEQEQ-UHTZMRCNSA-N
|
|||
CAS Number |
CAS 121032-29-9
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
3723610, 10039476, 12015013, 14775959, 14922755, 36059494, 46506325, 47206859, 50125808, 57410212, 71821532, 80796537, 99437030, 103771095, 111631431, 124757087, 125163891, 126592934, 128235087, 131296361, 134223564, 134338255, 135108408, 135611106, 136368093, 136375852, 136949086, 137006687, 140519970, 144074932, 144115623, 144206267, 151991744, 152059610, 152213835, 152344115, 160964602, 162011505, 164175279, 170464759, 172914301, 174477095, 175266277, 176484949, 178103668, 179116965, 185998139, 196376328, 210274937, 210280574
|
|||
ChEBI ID |
CHEBI:63612
|
|||
ADReCS Drug ID | BADD_D01549 | |||
SuperDrug ATC ID |
L01BB07
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | DNA synthesis (DNA synth) | Target Info | Binder | [4] |
References | Top | |||
---|---|---|---|---|
REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7090). | |||
REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
REF 3 | 2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006). | |||
REF 4 | Nelarabine. Drugs. 2008;68(4):439-47. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.