Target Information
| Target General Information | Top | |||||
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| Target ID |
T23831
(Former ID: TTDR00602)
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| Target Name |
Haemophilus influenzae NadR protein (Hae-influ nadR)
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| Synonyms |
nadR; Transcriptional regulator nadR
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| Gene Name |
Hae-influ nadR
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
This enzyme has twoactivities: nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the AMP moiety of ATP to nicotinamide ribonucleotide to form NAD(+).
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| BioChemical Class |
Nicotinamide ribonucleoside uptake permease
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| UniProt ID | ||||||
| Sequence |
MGFTTGREFHPALRMRAKYNAKYLGTKSEREKYFHLAYNKHTQFLRYQEQIMSKTKEKKV
GVIFGKFYPVHTGHINMIYEAFSKVDELHVIVCSDTVRDLKLFYDSKMKRMPTVQDRLRW MQQIFKYQKNQIFIHHLVEDGIPSYPNGWQSWSEAVKTLFHEKHFEPSIVFSSEPQDKAP YEKYLGLEVSLVDPDRTFFNVSATKIRTTPFQYWKFIPKEARPFFAKTVAILGGESSGKS VLVNKLAAVFNTTSAWEYGREFVFEKLGGDEQAMQYSDYPQMALGHQRYIDYAVRHSHKI AFIDTDFITTQAFCIQYEGKAHPFLDSMIKEYPFDVTILLKNNTEWVDDGLRSLGSQKQR QQFQQLLKKLLDKYKVPYIEIESPSYLDRYNQVKAVIEKVLNEEEISELQNTTFPIKGTS Q Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: Nicotinamide-Adenine-Dinucleotide | Ligand Info | |||||
| Structure Description | NADR PROTEIN FROM HAEMOPHILUS INFLUENZAE | PDB:1LW7 | ||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | Yes | [2] |
| PDB Sequence |
EKKVGVIFGK
66 FYPVHTGHIN76 IYEAFSKVDE87 LHVIVCSDTV97 RDLKLFYDSK107 KRPTVQDRLR 119 WQQIFKYQKN130 QIFIHHLVED140 GIPSYPNGWQ150 SWSEAVKTLF160 HEKHFEPSIV 170 FSSEPQDKAP180 YEKYLGLEVS190 LVDPDRTFFN200 VSATKIRTTP210 FQYWKFIPKE 220 ARPFFAKTVA230 ILGGESSGKS240 VLVNKLAAVF250 NTTSAWEYGR260 EFVFEKLGGD 270 EQAMQYSDYP280 QALGHQRYID291 YAVRHSHKIA301 FIDTDFITTQ311 AFCIQYEGKA 321 HPFLDSIKEY332 PFDVTILLKN342 NTEQKQRQQF363 QQLLKKLLDK373 YKVPYIEIES 383 PSYLDRYNQV393 KAVIEKVLNE403 EEISELQN
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PHE64
3.094
GLY65
3.664
LYS66
3.166
PHE67
3.390
HIS71
3.126
GLY73
4.095
HIS74
3.370
CYS93
3.581
ARG98
3.109
GLU139
2.557
ILE142
3.817
PRO143
2.521
SER144
3.917
TYR145
3.168
PRO146
4.882
ASN147
3.441
GLY148
2.814
TRP149
2.627
TRP152
3.254
PHE171
4.470
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| Ligand Name: Selenomethionine | Ligand Info | |||||
| Structure Description | NADR PROTEIN FROM HAEMOPHILUS INFLUENZAE | PDB:1LW7 | ||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | Yes | [2] |
| PDB Sequence |
EKKVGVIFGK
66 FYPVHTGHIN76 IYEAFSKVDE87 LHVIVCSDTV97 RDLKLFYDSK107 KRPTVQDRLR 119 WQQIFKYQKN130 QIFIHHLVED140 GIPSYPNGWQ150 SWSEAVKTLF160 HEKHFEPSIV 170 FSSEPQDKAP180 YEKYLGLEVS190 LVDPDRTFFN200 VSATKIRTTP210 FQYWKFIPKE 220 ARPFFAKTVA230 ILGGESSGKS240 VLVNKLAAVF250 NTTSAWEYGR260 EFVFEKLGGD 270 EQAMQYSDYP280 QALGHQRYID291 YAVRHSHKIA301 FIDTDFITTQ311 AFCIQYEGKA 321 HPFLDSIKEY332 PFDVTILLKN342 NTEQKQRQQF363 QQLLKKLLDK373 YKVPYIEIES 383 PSYLDRYNQV393 KAVIEKVLNE403 EEISELQN
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ILE63
3.257
PHE67
4.106
TYR68
3.347
VAL70
3.182
THR72
4.992
GLY73
3.251
HIS74
2.859
ILE75
3.093
ASN76
1.327
ILE78
1.328
TYR79
3.185
GLU80
2.937
ALA81
2.977
PHE82
4.874
VAL90
4.199
VAL92
3.934
ASP99
4.994
LEU100
4.185
LEU102
4.305
PHE103
3.091
SER106
3.014
LYS107
1.329
LYS109
1.332
ARG110
1.323
PRO112
1.340
THR113
3.371
ASP116
4.681
ARG117
3.311
LEU118
3.072
ARG119
3.214
TRP120
1.317
GLN122
1.328
GLN123
3.023
ILE124
3.174
PHE125
2.984
LYS126
4.767
ILE134
3.446
PHE171
3.832
SER172
3.982
SER173
4.425
VAL192
4.277
ARG207
3.874
PHE224
3.544
PHE225
3.598
TYR258
3.416
GLY259
4.040
PHE262
4.658
VAL263
4.714
MET274
3.481
ASP278
3.110
TYR279
3.108
PRO280
3.308
GLN281
1.325
ALA283
1.323
LEU284
3.309
GLY285
3.054
HIS286
2.937
GLN287
3.769
PHE307
3.750
PHE324
3.012
LEU325
2.962
ASP326
3.287
SER327
1.334
ILE329
1.331
LYS330
3.294
GLU331
3.045
TYR332
2.928
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| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
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There is no similarity protein (E value < 0.005) for this target
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| References | Top | |||||
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| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||||
| REF 2 | Crystal structure of Haemophilus influenzae NadR protein. A bifunctional enzyme endowed with NMN adenyltransferase and ribosylnicotinimide kinase activities. J Biol Chem. 2002 Sep 6;277(36):33291-9. | |||||
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