Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T23831 Target Info
Target Name Haemophilus influenzae NadR protein (Hae-influ nadR)
Synonyms nadR; Transcriptional regulator nadR
Target Type Literature-reported Target
Gene Name Hae-influ nadR
Biochemical Class Nicotinamide ribonucleoside uptake permease
UniProt ID
NADR_HAEIN
Drug Binding Sites of Target  Top
Ligand Name: Nicotinamide-Adenine-Dinucleotide Ligand Info
Structure Description NADR PROTEIN FROM HAEMOPHILUS INFLUENZAE PDB:1LW7
Method X-ray diffraction Resolution 2.90 Å Mutation Yes [1]
PDB Sequence
EKKVGVIFGK
66
FYPVHTGHIN
76
IYEAFSKVDE
87
LHVIVCSDTV
97
RDLKLFYDSK
107

KRPTVQDRLR
119
WQQIFKYQKN
130
QIFIHHLVED
140
GIPSYPNGWQ
150
SWSEAVKTLF
160

HEKHFEPSIV
170
FSSEPQDKAP
180
YEKYLGLEVS
190
LVDPDRTFFN
200
VSATKIRTTP
210

FQYWKFIPKE
220
ARPFFAKTVA
230
ILGGESSGKS
240
VLVNKLAAVF
250
NTTSAWEYGR
260

EFVFEKLGGD
270
EQAMQYSDYP
280
QALGHQRYID
291
YAVRHSHKIA
301
FIDTDFITTQ
311

AFCIQYEGKA
321
HPFLDSIKEY
332
PFDVTILLKN
342
NTEQKQRQQF
363
QQLLKKLLDK
373

YKVPYIEIES
383
PSYLDRYNQV
393
KAVIEKVLNE
403
EEISELQN
Residue
Distance (Å)
PHE64
3.094
GLY65
3.664
LYS66
3.166
PHE67
3.390
HIS71
3.126
GLY73
4.095
HIS74
3.370
CYS93
3.581
ARG98
3.109
GLU139
2.557
ILE142
3.817
PRO143
2.521
SER144
3.917
TYR145
3.168
PRO146
4.882
ASN147
3.441
GLY148
2.814
TRP149
2.627
TRP152
3.254
PHE171
4.470
Residue
Distance (Å)
SER172
2.520
SER173
2.688
GLU174
2.701
VAL192
4.735
ASP193
3.630
ARG196
3.433
PHE198
4.143
PHE199
2.843
ASN200
4.899
VAL201
2.785
SER202
4.994
SER254
2.967
ALA255
3.171
TRP256
2.668
ARG288
4.316
TYR289
3.055
ILE290
4.896
TYR292
3.185
ALA293
3.816
Ligand Name: Selenomethionine Ligand Info
Structure Description NADR PROTEIN FROM HAEMOPHILUS INFLUENZAE PDB:1LW7
Method X-ray diffraction Resolution 2.90 Å Mutation Yes [1]
PDB Sequence
EKKVGVIFGK
66
FYPVHTGHIN
76
IYEAFSKVDE
87
LHVIVCSDTV
97
RDLKLFYDSK
107

KRPTVQDRLR
119
WQQIFKYQKN
130
QIFIHHLVED
140
GIPSYPNGWQ
150
SWSEAVKTLF
160

HEKHFEPSIV
170
FSSEPQDKAP
180
YEKYLGLEVS
190
LVDPDRTFFN
200
VSATKIRTTP
210

FQYWKFIPKE
220
ARPFFAKTVA
230
ILGGESSGKS
240
VLVNKLAAVF
250
NTTSAWEYGR
260

EFVFEKLGGD
270
EQAMQYSDYP
280
QALGHQRYID
291
YAVRHSHKIA
301
FIDTDFITTQ
311

AFCIQYEGKA
321
HPFLDSIKEY
332
PFDVTILLKN
342
NTEQKQRQQF
363
QQLLKKLLDK
373

YKVPYIEIES
383
PSYLDRYNQV
393
KAVIEKVLNE
403
EEISELQN
Residue
Distance (Å)
ILE63
3.257
PHE67
4.106
TYR68
3.347
VAL70
3.182
THR72
4.992
GLY73
3.251
HIS74
2.859
ILE75
3.093
ASN76
1.327
ILE78
1.328
TYR79
3.185
GLU80
2.937
ALA81
2.977
PHE82
4.874
VAL90
4.199
VAL92
3.934
ASP99
4.994
LEU100
4.185
LEU102
4.305
PHE103
3.091
SER106
3.014
LYS107
1.329
LYS109
1.332
ARG110
1.323
PRO112
1.340
THR113
3.371
ASP116
4.681
ARG117
3.311
LEU118
3.072
ARG119
3.214
TRP120
1.317
GLN122
1.328
GLN123
3.023
ILE124
3.174
Residue
Distance (Å)
PHE125
2.984
LYS126
4.767
ILE134
3.446
PHE171
3.832
SER172
3.982
SER173
4.425
VAL192
4.277
ARG207
3.874
PHE224
3.544
PHE225
3.598
TYR258
3.416
GLY259
4.040
PHE262
4.658
VAL263
4.714
MET274
3.481
ASP278
3.110
TYR279
3.108
PRO280
3.308
GLN281
1.325
ALA283
1.323
LEU284
3.309
GLY285
3.054
HIS286
2.937
GLN287
3.769
PHE307
3.750
PHE324
3.012
LEU325
2.962
ASP326
3.287
SER327
1.334
ILE329
1.331
LYS330
3.294
GLU331
3.045
TYR332
2.928
References  Top
REF 1 Crystal structure of Haemophilus influenzae NadR protein. A bifunctional enzyme endowed with NMN adenyltransferase and ribosylnicotinimide kinase activities. J Biol Chem. 2002 Sep 6;277(36):33291-9.

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