Target Information

Target General Information

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Target ID

T23050

Target Name

Pseudomonas LPS-assembly protein LptD (Pseudo lptD)

Synonyms

ostA; Pseudo imp

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Gene Name

Pseudo lptD

Target Type

Clinical trial target

[1]

Disease

[+] 1 Target-related Diseases

Medical/surgical procedure injury [ICD-11: PK80-PK81]

Function

Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.

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BioChemical Class

LptD family

UniProt ID

LPTD_PSEAE

Sequence

MAVKSLVFRRKFPLLVTGSLLALQPVAALTVQAADQFDCKVSATGGWDCSPLQNANANLP
PRPAHTATSVSTAAAGSSVSGSGGETVEAEPTQRLVTESGGRALKSRSADYSHLDWIPRE
KLTAAQLAEIGPYCGGSYIEPVRPGMDDGAPSDESPTYVSAKASRYEQEKQIATLAGDVV
LRQGSMQVEGDEANLHQLENRGELVGNVKLRDKGMLVVGDHAQVQLDNGEAQVDNAEYVI
HKAHARGSALYAKRSENAIIMLKDGTYTRCEPSSNAWTLKGNNVKLNPATGFGTATNATL
RVKDFPVFYTPYIYFPIDDRRQSGFLPPSFSSTSDTGFTLVTPYYFNLAPNYDATLYPRY
MAKRGMMLEGEFRYLTHSSEGIVNAAYLNDKDDHREGFPDYSKDRWLYGLKNTTGLDSRW
LAEVDYTRISDPYYFQDLDTDLGVGSTTYVNQRGTLTYRGDTFTGRLNAQAYQLATTTDV
TPYDRLPQITFDGFLPYNPGGMQFTYGTEFVRFDRDLDENIYFNDDGSIRGKRPDASLQG
LARATGDRMHLEPGMSLPMTRSWGYVTPTLKYLYTKYDLDLDSQGKTDLNKRDESFDSNQ
DRSLPLVKVDSGLYFDRDTTFAGTPFRQTLEPRAMYLYVPYKDQDSLPVFDTSEPSFSYD
SLWRENRFTGKDRIGDANQLSLGVTSRFIEENGFERASISAGQIYYFRDRRVQLPGLTEK
DLKRLNLDPSGLDNDSWRSPYAFAGQYRFNRDWRINSDFNWNPNTSRTESGSAIFHYQPE
VDPGKVVNVGYRYRADARRFDSSRGTFRYGNENDIIKQHDFSVIWPLVPQWSVLARWQYD
YNKNRTLEAFGGFEYDSCCWKLRLINRYWLDVDDDAFLVQSEKADRGIFLQIVLKGLGGI
VGNKTEMFLDKGIQGYRQREDQAM

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Drugs and Modes of Action

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Clinical Trial Drug(s)

[+] 1 Clinical Trial Drugs

Murepavadin

Drug Info

Phase 3

Ventilator-associated pneumonia

[1]

Mode of Action

[+] 1 Modes of Action

Antagonist

[+] 1 Antagonist drugs

Murepavadin

Drug Info

[1]

Drug Binding Sites of Target

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Ligand Name: (Hydroxyethyloxy)Tri(Ethyloxy)Octane

Ligand Info

Structure Description

The LPS Transporter LptDE from Pseudomonas aeruginosa, core complex

PDB:5IVA

Method

X-ray diffraction

Resolution

2.99 Å

Mutation

[2]

PDB Sequence

IDDRRQSGFL

⁴⁸

PPSFSSTSDT

⁵⁸

GFTLVTPYYF

⁶⁸

NLAPNYDATL

⁷⁸

YPRYMAKRGM

⁸⁸

MLEGEFRYLT

⁹⁸

HSSEGIVNAA

¹⁰⁸

YLNDKDDHRE

¹¹⁸

GFPDYSKDRW

¹²⁸

LYGLKNTTGL

¹³⁸

DSRWLAEVDY

¹⁴⁸

TRISDPYYFQ

¹⁵⁸

DLDTDLGVGS

¹⁶⁸

TTYVNQRGTL

¹⁷⁸

TYRGDTFTGR

¹⁸⁸

LNAQAYQLAT

¹⁹⁸

TTDVTPYDRL

²⁰⁸

PQITFDGFLP

²¹⁸

YNPGGMQFTY

²²⁸

GTEFVRFDRD

²³⁸

LDENIYFNDD

²⁴⁸

GSIRGKRPDA

²⁵⁸

SLQGLARATG

²⁶⁸

DRMHLEPGMS

²⁷⁸

LPMTRSWGYV

²⁸⁸

TPTLKYLYTK

²⁹⁸

YDLDLDSQGK

³⁰⁸

TDLNKRDESF

³¹⁸

DSNQDRSLPL

³²⁸

VKVDSGLYFD

³³⁸

RDTTFAGTPF

³⁴⁸

RQTLEPRAMY

³⁵⁸

LYVPYKDQDS

³⁶⁸

LPVFDTSEPS

³⁷⁸

FSYDSLWREN

³⁸⁸

RFTGKDRIGD

³⁹⁸

ANQLSLGVTS

⁴⁰⁸

RFIEENGFER

⁴¹⁸

ASISAGQIYY

⁴²⁸

FRDRRVQLPG

⁴³⁸

LTEKDLKRLN

⁴⁴⁸

LDPSGLDNDS

⁴⁵⁸

WRSPYAFAGQ

⁴⁶⁸

YRFNRDWRIN

⁴⁷⁸

SDFNWNPNTS

⁴⁸⁸

RTESGSAIFH

⁴⁹⁸

YQPEVDPGKV

⁵⁰⁸

VNVGYRYRAD

⁵¹⁸

ARRFDSSRGT

⁵²⁸

FRYGNENDII

⁵³⁸

KQHDFSVIWP

⁵⁴⁸

LVPQWSVLAR

⁵⁵⁸

WQYDYNKNRT

⁵⁶⁸

LEAFGGFEYD

⁵⁷⁸

SCCWKLRLIN

⁵⁸⁸

RYWLDVDDDA

⁵⁹⁸

FLVQSEKADR

⁶⁰⁸

GIFLQIVLK

Residue

Distance (Å)

SER54

4.505

SER56

4.901

TYR130

3.862

TYR148

3.119

ARG150

3.772

GLN174

3.384

ARG175

4.313

GLY176

4.356

ALA191

4.109

ALA193

3.763

TYR194

4.772

ASP206

4.177

LEU208

4.357

THR230

4.561

LEU273

3.921

PRO275

3.733

TYR294

3.466

TYR296

4.262

VAL329

4.762

TYR358

3.264

TYR360

3.702

ASN400

3.477

Residue

Distance (Å)

PHE429

3.548

PHE543

4.001

VAL545

4.791

VAL555

3.987

ALA557

4.124

ARG558

4.427

TRP559

3.499

TYR561

3.238

TYR563

4.055

ASN566

4.987

THR568

4.353

ALA571

3.523

PHE572

4.056

GLY573

3.352

GLY574

3.885

PHE575

3.558

ASN588

3.351

ARG589

4.218

TYR590

3.570

ARG608

3.650

GLY609

3.950

ILE610

4.308

Click to View More Binding Site Information of This Target with Different Ligands

Different Human System Profiles of Target	Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target. A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020). Human Similarity Proteins

Different Human System Profiles of Target

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Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.

A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).

Human Similarity Proteins

There is no similarity protein (E value < 0.005) for this target

References

Top

REF 1

Anti-ageing pipeline starts to mature.Nat Rev Drug Discov. 2018 Sep;17(9):609-612.

REF 2

Structural and Functional Characterization of the LPS Transporter LptDE from Gram-Negative Pathogens. Structure. 2016 Jun 7;24(6):965-976.

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