Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T23050 Target Info
Target Name Pseudomonas LPS-assembly protein LptD (Pseudo lptD)
Synonyms ostA; Pseudo imp
Target Type Clinical trial Target
Gene Name Pseudo lptD
Biochemical Class LptD family
UniProt ID
LPTD_PSEAE
Drug Binding Sites of Target  Top
Ligand Name: (Hydroxyethyloxy)Tri(Ethyloxy)Octane Ligand Info
Structure Description The LPS Transporter LptDE from Pseudomonas aeruginosa, core complex PDB:5IVA
Method X-ray diffraction Resolution 2.99 Å Mutation No [1]
PDB Sequence
IDDRRQSGFL
48
PPSFSSTSDT
58
GFTLVTPYYF
68
NLAPNYDATL
78
YPRYMAKRGM
88

MLEGEFRYLT
98
HSSEGIVNAA
108
YLNDKDDHRE
118
GFPDYSKDRW
128
LYGLKNTTGL
138

DSRWLAEVDY
148
TRISDPYYFQ
158
DLDTDLGVGS
168
TTYVNQRGTL
178
TYRGDTFTGR
188

LNAQAYQLAT
198
TTDVTPYDRL
208
PQITFDGFLP
218
YNPGGMQFTY
228
GTEFVRFDRD
238

LDENIYFNDD
248
GSIRGKRPDA
258
SLQGLARATG
268
DRMHLEPGMS
278
LPMTRSWGYV
288

TPTLKYLYTK
298
YDLDLDSQGK
308
TDLNKRDESF
318
DSNQDRSLPL
328
VKVDSGLYFD
338

RDTTFAGTPF
348
RQTLEPRAMY
358
LYVPYKDQDS
368
LPVFDTSEPS
378
FSYDSLWREN
388

RFTGKDRIGD
398
ANQLSLGVTS
408
RFIEENGFER
418
ASISAGQIYY
428
FRDRRVQLPG
438

LTEKDLKRLN
448
LDPSGLDNDS
458
WRSPYAFAGQ
468
YRFNRDWRIN
478
SDFNWNPNTS
488

RTESGSAIFH
498
YQPEVDPGKV
508
VNVGYRYRAD
518
ARRFDSSRGT
528
FRYGNENDII
538

KQHDFSVIWP
548
LVPQWSVLAR
558
WQYDYNKNRT
568
LEAFGGFEYD
578
SCCWKLRLIN
588

RYWLDVDDDA
598
FLVQSEKADR
608
GIFLQIVLK
Residue
Distance (Å)
SER54
4.505
SER56
4.901
TYR130
3.862
TYR148
3.119
ARG150
3.772
GLN174
3.384
ARG175
4.313
GLY176
4.356
ALA191
4.109
ALA193
3.763
TYR194
4.772
ASP206
4.177
LEU208
4.357
THR230
4.561
LEU273
3.921
PRO275
3.733
TYR294
3.466
TYR296
4.262
VAL329
4.762
TYR358
3.264
TYR360
3.702
ASN400
3.477
Residue
Distance (Å)
PHE429
3.548
PHE543
4.001
VAL545
4.791
VAL555
3.987
ALA557
4.124
ARG558
4.427
TRP559
3.499
TYR561
3.238
TYR563
4.055
ASN566
4.987
THR568
4.353
ALA571
3.523
PHE572
4.056
GLY573
3.352
GLY574
3.885
PHE575
3.558
ASN588
3.351
ARG589
4.218
TYR590
3.570
ARG608
3.650
GLY609
3.950
ILE610
4.308
References  Top
REF 1 Structural and Functional Characterization of the LPS Transporter LptDE from Gram-Negative Pathogens. Structure. 2016 Jun 7;24(6):965-976.

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