Target Information

Target General Information

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Target ID

T16047 (Former ID: TTDS00120)

Target Name

Onchocerca Glutamate-gated chloride channel (Onchoc GluCl)

Synonyms

Glutamate-gated chloride channel

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Gene Name

Onchoc GluCl

Target Type

Successful target

[1]

Disease

[+] 2 Target-related Diseases

Onchocerciasis [ICD-11: 1F6A]

Strongyloidiasis [ICD-11: 1F6B]

Function

As postsynaptic receptors within the crustacean stomatogastric ganglion.

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BioChemical Class

Ion transport

UniProt ID

Q25634_ONCVO

Sequence

MNSFPIVCWNLAFLILVVAKKKLKEQEIIQRTLKDYDWRVRPRGNNLSWPDTGGPVLVSV
NIYLRSISKIDDVNMEYSAQFTFREEWNDARLGYERLADENTQVPPFVVLAASEQPDLTQ
QIWMPDTFFQNEKEARRHLIDKPNVLIRIHPDGQILYSVRLSLVLSCPMSLEYYPLDRQT
CLIDLASYAYTTDDIKYEWKVKNPIQQKEGLRQSLPSFELQDVLTEYCTSKTNTGEYSCA
RVLLLLRREYRFSYYLIQLYIPCIMLVVVSWVSFWLDKDAVPARVSLGVTTLLTMTTQAS
GINAKLPPVSYIKAVDVWIGVCLAFIFGALLEYALVNYHGRQEFLKKEKKK

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Drugs and Modes of Action

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Approved Drug(s)

[+] 2 Approved Drugs

Ivermectin

Drug Info

Approved

Intestinal strongyloidiasis due to nematode parasite

[2], [3]

Moxidectin

Drug Info

Approved

River blindness

[4]

Mode of Action

[+] 2 Modes of Action

Activator

[+] 1 Activator drugs

Ivermectin

Drug Info

[1]

Modulator

[+] 1 Modulator drugs

Moxidectin

Drug Info

[4]

Different Human System Profiles of Target	Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target. A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020). Human Similarity Proteins

Different Human System Profiles of Target

Top

Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.

A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).

Human Similarity Proteins

There is no similarity protein (E value < 0.005) for this target

References

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REF 1

Inhibitory neurotransmission and olfactory memory in honeybees. Neurobiol Learn Mem. 2008 Nov;90(4):589-95.

REF 2

URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2373).

REF 3

Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.

REF 4

2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.

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