Target Information
| Target General Information | Top | |||||
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| Target ID |
T07466
(Former ID: TTDR00030)
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| Target Name |
Bacterial Glycosyltransferase MurG (Bact murG)
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| Synonyms |
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; MurG
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| Gene Name |
Bact murG
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II).
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| BioChemical Class |
Hexosyltransferase
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| UniProt ID | ||||||
| EC Number |
EC 2.4.1.227
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| Sequence |
MSGQGKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEADLVPKHGIEIDFI
RISGLRGKGIKALIAAPLRIFNAWRQARAIMKAYKPDVVLGMGGYVSGPGGLAAWSLGIP VVLHEQNGIAGLTNKWLAKIATKVMQAFPGAFPNAEVVGNPVRTDVLALPLPQQRLAGRE GPVRVLVVGGSQGARILNQTMPQVAAKLGDSVTIWHQSGKGSQQSVEQAYAEAGQPQHKV TEFIDDMAAAYAWADVVVCRSGALTVSEIAAAGLPALFVPFQHKDRQQYWNALPLEKAGA AKIIEQPQLSVDAVANTLAGWSRETLLTMAERARAASIPDATERVANEVSRVARA Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: Uridine-Diphosphate-N-Acetylglucosamine | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF MURG:GLCNAC COMPLEX | PDB:1NLM | ||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [2] |
| PDB Sequence |
KRLMVMAGGT
16 GGHVFPGLAV26 AHHLMAQGWQ36 VRWLGTADRM46 EADLVPKHGI56 EIDFIRISGL 66 RGKGIKALIA76 APLRIFNAWR86 QARAIMKAYK96 PDVVLGMGGY106 VSGPGGLAAW 116 SLGIPVVLHE126 QNGIAGLTNK136 WLAKIATKVM146 QAFPGAFPNA156 EVVGNPVRTD 166 VLALPLPQQR176 LAGREGPVRV186 LVVGGSQGAR196 ILNQTMPQVA206 AKLGDSVTIW 216 HQSGKGSQQS226 VEQAYAEAGQ236 PQHKVTEFID246 DMAAAYAWAD256 VVVCRSGALT 266 VSEIAAAGLP276 ALFVPFQHKD286 RQQYWNALPL296 EKAGAAKIIE306 QPQLSVDAVA 316 NTLAGWSRET326 LLTMAERARA336 ASIPDATERV346 ANEVSRVARA356 |
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GLY18
3.275
ASN128
2.644
ARG164
2.723
VAL189
3.777
GLY191
3.589
SER192
3.423
GLN193
4.539
GLN218
3.167
PHE244
3.364
ILE245
3.032
ASP246
4.963
MET248
3.416
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| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
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There is no similarity protein (E value < 0.005) for this target
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| Target Affiliated Biological Pathways | Top | |||||
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| Panther Pathway | [+] 1 Panther Pathways | + | ||||
| 1 | Peptidoglycan biosynthesis | |||||
| References | Top | |||||
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| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||||
| REF 2 | Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):845-9. | |||||
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