Target Validation Information
TTD ID	T92777
Target Name	Intestinal maltase-glucoamylase (MGAM)
Type of Target	Successful
Drug Potency against Target	Acarbose	Drug Info	IC50 = 0.05 mM
	1,4-dideoxy-1,4-imino-D-arabinito	Drug Info	IC50 = 840 nM	[1]
	2,5-Dideoxy-2,5-imino-D-mannitol	Drug Info	IC50 = 2000 nM	[1]
	4'-(p-toluenesulfonamide)-3,4-dihydroxy chalcone	Drug Info	Ki = 240 nM	[2]
	De-O-sulfonated kotalanol	Drug Info	Ki = 30 nM	[4]
	Deoxynojirimycin	Drug Info	IC50 = 4600 nM	[5]
	KOTALANOL	Drug Info	Ki = 190 nM	[4]
	PONKORANOL	Drug Info	Ki = 170 nM	[3]
	SALACINOL	Drug Info	Ki = 1000 nM	[4]
References
REF 1	New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii. J Nat Prod. 2002 Feb;65(2):198-202.
REF 2	Sulfonamide chalcone as a new class of alpha-glucosidase inhibitors. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5514-6.
REF 3	Probing the active-site requirements of human intestinal N-terminal maltase glucoamylase: the effect of replacing the sulfate moiety by a methyl et... Bioorg Med Chem Lett. 2010 Oct 1;20(19):5686-9.
REF 4	Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membe... Bioorg Med Chem. 2010 Nov 15;18(22):7794-8.
REF 5	Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. J Med Chem. 1994 Oct 28;37(22):3701-6.

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