Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0AD5C
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| Former ID |
DAP000174
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| Drug Name |
Acarbose
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| Synonyms |
acarbose; 56180-94-0; Glucobay; Precose; Prandase; C25H43NO18; CHEBI:2376; CHEMBL3734896; BAY-g 5421; 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-D-glucopyranose; SMR000466376; SR-01000759407; Acarbose/; Acarbose [USAN:BAN:INN:JAN]; Acarbose,(S); Precose (TN); AC1L26GM; Acarbose (JAN/USAN/INN); MLS006011898; MLS000759506; MLS001424056; SPECTRUM1505172; SCHEMBL5316305; CHEMBL404271; BDBM23406; MolPort-002-507-369
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| Drug Type |
Small molecular drug
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| Indication | Diabetic complication [ICD-11: 5A2Y; ICD-9: 253.5, 588.1] | Approved | [1], [2] | |
| Cardiovascular disease [ICD-11: BA00-BE2Z; ICD-10: I00-I99] | Phase 3 | [1], [2] | ||
| Therapeutic Class |
Hypoglycemic Agents
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| Company |
Bayer
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| Structure |
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Download2D MOL |
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| Formula |
C25H43NO18
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| Canonical SMILES |
CC1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)NC4C=C(C(C(C4O)O)O)CO
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| InChI |
1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23?,24-,25-/m1/s1
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| InChIKey |
XUFXOAAUWZOOIT-UGEKTDRHSA-N
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| CAS Number |
CAS 56180-94-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
825251, 834618, 7885684, 7888168, 10299511, 12012879, 14964694, 26702476, 36887324, 46391424, 46393315, 49689717, 49853891, 50752736, 57404612, 81062582, 87544180, 92729723, 99437067, 103023822, 103585278, 104038074, 104631735, 123121432, 124757133, 125083567, 125163937, 134338965, 134339490, 135692087, 136368136, 144115532, 144205150, 162023511, 162037530, 170464784, 172386359, 175269637, 175611917, 176484930, 177748581, 178103397, 179116541, 210279189, 210281512, 223984695, 226406984, 241376066, 250133961, 252156703
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| ChEBI ID |
CHEBI:2376
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| ADReCS Drug ID | BADD_D00018 | |||
| SuperDrug ATC ID |
A10BF01
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| SuperDrug CAS ID |
cas=056180940
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Acidaminococcales | ||||
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Studied Microbe: Acidaminococcus fermentans
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Acidaminococcus fermentans was decreased by Acarbose (pre abundance: 6.23E-05; post abundance: 5.00E-04; p = 1.78E-02; q = 4.47E-02). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes putredinis
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Alistipes putredinis was increased by Acarbose (pre abundance: 2.25E-02; post abundance: 7.08E-03; p = 2.35E-07; q = 1.01E-05). | |||
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Studied Microbe: Alistipes shahii
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Alistipes shahii was decreased by Acarbose (pre abundance: 4.78E-03; post abundance: 3.42E-03; p = 5.13E-03; q = 1.82E-02). | |||
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Studied Microbe: Alistipes sp. HGB5
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Alistipes sp. HGB5 was decreased by Acarbose (pre abundance: 1.42E-03; post abundance: 7.72E-04; p = 1.22E-03; q = 6.00E-03). | |||
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Studied Microbe: Bacteroides caccae
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bacteroides caccae was decreased by Acarbose (pre abundance: 4.06E-03; post abundance: 1.96E-03; p = 3.09E-03; q = 1.26E-02). | |||
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Studied Microbe: Bacteroides clarus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bacteroides clarus was decreased by Acarbose (pre abundance: 1.27E-03; post abundance: 1.90E-04; p = 4.34E-03; q = 1.63E-02). | |||
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Studied Microbe: Bacteroides dorei
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bacteroides dorei was decreased by Acarbose (pre abundance: 8.30E-02; post abundance: 3.50E-02; p = 2.35E-07; q = 1.01E-05). | |||
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Studied Microbe: Bacteroides finegoldii
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bacteroides finegoldii was decreased by Acarbose (pre abundance: 3.13E-03; post abundance: 5.80E-04; p = 8.55E-05; q = 6.95E-04). | |||
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Studied Microbe: Bacteroides fragilis enterotoxigenic
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Acarbose (adjusted p-values: 4.23E-04). | |||
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Studied Microbe: Bacteroides intestinalis
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bacteroides intestinalis was decreased by Acarbose (pre abundance: 3.31E-03; post abundance: 5.93E-04; p = 9.35E-06; q = 1.76E-04). | |||
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Studied Microbe: Bacteroides plebeius
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bacteroides plebeius was decreased by Acarbose (pre abundance: 5.45E-02; post abundance: 2.97E-02; p = 2.21E-03; q = 9.79E-03). | |||
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Studied Microbe: Bacteroides stercoris
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bacteroides stercoris was increased by Acarbose (pre abundance: 2.25E-02; post abundance: 8.74E-03; p = 8.48E-05; q = 6.95E-04). | |||
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Studied Microbe: Bacteroides thetaiotaomicron
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bacteroides thetaiotaomicron was increased by Acarbose (pre abundance: 1.16E-02; post abundance: 3.19E-03; p = 1.73E-05; q = 2.16E-04). | |||
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Studied Microbe: Bacteroides uniformis
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Acarbose (adjusted p-values: 1.16E-03). | |||
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Studied Microbe: Bacteroides uniformis
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bacteroides uniformis was decreased by Acarbose (pre abundance: 3.34E-02; post abundance: 1.65E-02; p = 2.02E-04; q = 1.42E-03). | |||
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Studied Microbe: Bacteroides vulgatus
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Acarbose (adjusted p-values: 6.57E-04). | |||
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Studied Microbe: Bacteroides vulgatus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Acarbose (pre abundance: 8.30E-02; post abundance: 3.50E-02; p = 2.35E-07; q = 1.01E-05). | |||
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Studied Microbe: Bacteroides xylanisolvens
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides xylanisolvens was decreased by Acarbose (adjusted p-values: 4.04E-04). | |||
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Studied Microbe: Bacteroides xylanisolvens
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bacteroides xylanisolvens was increased by Acarbose (pre abundance: 1.02E-02; post abundance: 6.07E-03; p = 1.95E-02; q = 4.81E-02). | |||
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Studied Microbe: Odoribacter splanchnicus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Acarbose (pre abundance: 2.21E-03; post abundance: 7.71E-04; p = 3.73E-06; q = 8.63E-05). | |||
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Studied Microbe: Parabacteroides distasonis
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Parabacteroides distasonis was increased by Acarbose (pre abundance: 1.22E-02; post abundance: 1.73E-02; p = 1.08E-02; q = 3.15E-02). | |||
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Studied Microbe: Prevotella copri
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Prevotella copri was increased by Acarbose (pre abundance: 1.03E-01; post abundance: 1.34E-01; p = 8.17E-03; q = 2.67E-02). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bifidobacterium adolescentis was increased by Acarbose (pre abundance: 2.89E-03; post abundance: 4.05E-02; p = 7.08E-05; q = 6.45E-04). | |||
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Studied Microbe: Bifidobacterium breve
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bifidobacterium breve was increased by Acarbose (pre abundance: 1.40E-04; post abundance: 2.60E-03; p = 1.45E-02; q = 3.73E-02). | |||
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Studied Microbe: Bifidobacterium dentium
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bifidobacterium dentium was decreased by Acarbose (pre abundance: 5.83E-05; post abundance: 4.51E-04; p = 5.14E-03; q = 1.82E-02). | |||
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Studied Microbe: Bifidobacterium longum
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bifidobacterium longum was increased by Acarbose (pre abundance: 4.49E-03; post abundance: 5.35E-02; p = 5.38E-07; q = 2.02E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Burkholderiales | ||||
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Studied Microbe: Oxalobacter formigenes
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Oxalobacter formigenes was increased by Acarbose (pre abundance: 1.75E-04; post abundance: 3.61E-05; p = 4.82E-03; q = 1.77E-02). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Acarbose (pre abundance: 4.72E-03; post abundance: 1.43E-02; p = 7.29E-05; q = 6.45E-04). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Desulfovibrionales | ||||
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Studied Microbe: Bilophila wadsworthia
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bilophila wadsworthia was decreased by Acarbose (pre abundance: 2.21E-03; post abundance: 7.09E-04; p = 1.28E-07; q = 8.67E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Eggerthella lenta was increased by Acarbose (pre abundance: 3.28E-04; post abundance: 8.81E-05; p = 1.45E-06; q = 3.97E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Clostridium spiroforme
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Clostridium spiroforme was decreased by Acarbose (pre abundance: 9.29E-05; post abundance: 4.59E-05; p = 1.05E-02; q = 3.13E-02). | |||
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Studied Microbe: Eubacterium dolichum
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Eubacterium dolichum was increased by Acarbose (pre abundance: 1.35E-04; post abundance: 2.18E-06; p = 2.53E-03; q = 1.07E-02). | |||
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Studied Microbe: Holdemania filiformis
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Holdemania filiformis was increased by Acarbose (pre abundance: 2.38E-04; post abundance: 5.38E-05; p = 7.30E-07; q = 2.44E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Anaerotruncus colihominis
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Anaerotruncus colihominis was increased by Acarbose (pre abundance: 2.20E-04; post abundance: 3.67E-05; p = 4.08E-05; q = 3.96E-04). | |||
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Studied Microbe: Blautia hansenii
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Blautia hansenii was increased by Acarbose (pre abundance: 6.02E-04; post abundance: 9.63E-05; p = 3.17E-03; q = 1.27E-02). | |||
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Studied Microbe: Clostridium bolteae
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Clostridium bolteae was decreased by Acarbose (pre abundance: 1.87E-03; post abundance: 1.24E-04; p = 9.17E-08; q = 8.67E-06). | |||
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Studied Microbe: Clostridium leptum
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Clostridium leptum was decreased by Acarbose (pre abundance: 2.48E-04; post abundance: 1.03E-04; p = 2.25E-03; q = 9.83E-03). | |||
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Studied Microbe: Clostridium perfringens
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Acarbose (adjusted p-values: 4.37E-04). | |||
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Studied Microbe: Clostridium scindens
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Clostridium scindens was decreased by Acarbose (pre abundance: 8.51E-05; post abundance: 2.71E-05; p = 1.41E-03; q = 6.86E-03). | |||
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Studied Microbe: Clostridium sp. L2-50
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Clostridium sp. L2-50 was decreased by Acarbose (pre abundance: 3.35E-03; post abundance: 4.08E-05; p = 2.04E-04; q = 1.42E-03). | |||
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Studied Microbe: Eubacterium eligens
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Eubacterium eligens was increased by Acarbose (pre abundance: 1.92E-02; post abundance: 7.48E-03; p = 4.34E-04; q = 2.67E-03). | |||
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Studied Microbe: Eubacterium rectale
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Acarbose (adjusted p-values: 4.60E-04). | |||
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Studied Microbe: Eubacterium siraeum
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Eubacterium siraeum was decreased by Acarbose (pre abundance: 1.67E-03; post abundance: 2.90E-04; p = 2.87E-03; q = 1.18E-02). | |||
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Studied Microbe: Eubacterium ventriosum
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Eubacterium ventriosum was decreased by Acarbose (pre abundance: 1.86E-03; post abundance: 5.92E-04; p = 1.87E-04; q = 1.37E-03). | |||
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Studied Microbe: Lachnospiraceae bacterium 1 4 56FAA
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Lachnospiraceae bacterium 1 4 56FAA was increased by Acarbose (pre abundance: 2.67E-04; post abundance: 3.14E-05; p = 6.83E-05; q = 6.42E-04). | |||
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Studied Microbe: Pseudoflavonifractor capillosus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Pseudoflavonifractor capillosus was increased by Acarbose (pre abundance: 1.79E-04; post abundance: 5.14E-05; p = 7.99E-05; q = 6.87E-04). | |||
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Studied Microbe: Roseburia hominis
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Roseburia hominis was decreased by Acarbose (pre abundance: 1.53E-03; post abundance: 5.05E-04; p = 1.65E-05; q = 2.16E-04). | |||
|
Studied Microbe: Roseburia intestinalis
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Roseburia intestinalis was decreased by Acarbose (pre abundance: 5.24E-03; post abundance: 3.45E-04; p = 2.24E-05; q = 2.41E-04). | |||
|
Studied Microbe: Roseburia inulinivorans
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Roseburia inulinivorans was decreased by Acarbose (pre abundance: 9.25E-03; post abundance: 3.09E-03; p = 1.52E-05; q = 2.07E-04). | |||
|
Studied Microbe: Ruminococcaceae bacterium D16
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Ruminococcaceae bacterium D16 was decreased by Acarbose (pre abundance: 8.77E-05; post abundance: 4.59E-05; p = 1.32E-02; q = 3.51E-02). | |||
|
Studied Microbe: Ruminococcus lactaris
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Ruminococcus lactaris was decreased by Acarbose (pre abundance: 2.68E-03; post abundance: 9.22E-04; p = 1.86E-05; q = 2.18E-04). | |||
|
Studied Microbe: Ruminococcus sp. 5_1_39BFAA
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Ruminococcus sp. 5_1_39BFAA was decreased by Acarbose (pre abundance: 5.62E-03; post abundance: 3.18E-03; p = 5.29E-04; q = 2.95E-03). | |||
|
Studied Microbe: Ruminococcus torques
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Ruminococcus torques was increased by Acarbose (pre abundance: 3.02E-03; post abundance: 1.52E-02; p = 1.76E-03; q = 8.18E-03). | |||
|
Studied Microbe: unclassified Lachnospiraceae
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of unclassified Lachnospiraceae was decreased by Acarbose (pre abundance: 7.64E-04; post abundance: 5.82E-05; p = 2.87E-03; q = 1.18E-02). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Flavobacteriales | ||||
|
Studied Microbe: Capnocytophaga sp. oral taxon 329
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Capnocytophaga sp. oral taxon 329 was decreased by Acarbose (pre abundance: 3.41E-03; post abundance: 1.25E-03; p = 6.97E-03; q = 2.30E-02). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Fusobacteriales | ||||
|
Studied Microbe: Fusobacterium mortiferum
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Fusobacterium mortiferum was decreased by Acarbose (pre abundance: 2.17E-03; post abundance: 2.87E-04; p = 3.33E-03; q = 1.29E-02). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
|
Studied Microbe: Lactobacillus amylovorus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Lactobacillus amylovorus was decreased by Acarbose (pre abundance: 7.35E-05; post abundance: 1.26E-02; p = 9.72E-03; q = 2.97E-02). | |||
|
Studied Microbe: Lactobacillus crispatus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Lactobacillus crispatus was decreased by Acarbose (pre abundance: 9.42E-07; post abundance: 6.58E-04; p = 5.10E-03; q = 1.82E-02). | |||
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Studied Microbe: Lactobacillus gasseri
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Lactobacillus gasseri was increased by Acarbose (pre abundance: 1.07E-04; post abundance: 3.23E-03; p = 5.80E-04; q = 3.17E-03). | |||
|
Studied Microbe: Lactobacillus oris
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Lactobacillus oris was decreased by Acarbose (pre abundance: 4.40E-06; post abundance: 1.36E-03; p = 2.11E-03; q = 9.46E-03). | |||
|
Studied Microbe: Lactobacillus rhamnosus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Lactobacillus rhamnosus was increased by Acarbose (pre abundance: 0; post abundance: 2.36E-03; p = 1.10E-03; q = 5.50E-03). | |||
|
Studied Microbe: Lactobacillus salivarius
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Lactobacillus salivarius was decreased by Acarbose (pre abundance: 4.36E-06; post abundance: 2.39E-03; p = 1.10E-03; q = 5.50E-03). | |||
|
Studied Microbe: Streptococcus infantis
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Streptococcus infantis was decreased by Acarbose (pre abundance: 9.30E-05; post abundance: 1.54E-04; p = 4.82E-03; q = 1.77E-02). | |||
|
Studied Microbe: Streptococcus pneumoniae
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Streptococcus pneumoniae was decreased by Acarbose (pre abundance: 7.51E-05; post abundance: 1.45E-04; p = 1.83E-02; q = 4.55E-02). | |||
|
Studied Microbe: Streptococcus salivarius
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Streptococcus salivarius was decreased by Acarbose (pre abundance: 6.43E-03; post abundance: 1.32E-02; p = 6.38E-06; q = 1.37E-04). | |||
|
Studied Microbe: Streptococcus sp. C150
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Streptococcus sp. C150 was increased by Acarbose (pre abundance: 2.79E-04; post abundance: 2.98E-04; p = 4.32E-04; q = 2.67E-03). | |||
|
Studied Microbe: Streptococcus sp. M143
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Streptococcus sp. M143 was increased by Acarbose (pre abundance: 1.65E-06; post abundance: 1.82E-05; p = 1.45E-02; q = 3.73E-02). | |||
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Studied Microbe: Streptococcus thermophilus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Streptococcus thermophilus was increased by Acarbose (pre abundance: 3.43E-04; post abundance: 9.39E-04; p = 2.09E-05; q = 2.33E-04). | |||
|
Studied Microbe: Streptococcus vestibularis
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Streptococcus vestibularis was increased by Acarbose (pre abundance: 4.15E-04; post abundance: 8.84E-04; p = 1.08E-05; q = 1.80E-04). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Veillonellales | ||||
|
Studied Microbe: Megasphaera elsdenii
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Megasphaera elsdenii was decreased by Acarbose (pre abundance: 5.49E-04; post abundance: 2.61E-03; p = 3.21E-04; q = 2.10E-03). | |||
|
Studied Microbe: Veillonella atypica
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Veillonella atypica was decreased by Acarbose (pre abundance: 2.19E-03; post abundance: 1.30E-03; p = 1.25E-02; q = 3.39E-02). | |||
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Studied Microbe: Veillonella parvula
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Veillonella parvula was increased by Acarbose (pre abundance: 1.47E-03; post abundance: 8.07E-03; p = 5.71E-03; q = 1.95E-02). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
|
Studied Microbe: Bifidobacterium catenulatum/Bifidobacterium pseudocatenulatum
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bifidobacterium catenulatum-Bifidobacterium pseudocatenulatum complex was decreased by Acarbose (pre abundance: 6.24E-03; post abundance: 3.11E-02; p = 1.46E-05; q = 2.07E-04). | |||
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Studied Microbe: butyrate-producing bacterium
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of butyrate-producing bacterium was increased by Acarbose (pre abundance: 3.20E-03; post abundance: 1.30E-02; p = 1.24E-02; q = 3.39E-02). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Intestinal maltase-glucoamylase (MGAM) | Target Info | Modulator | [5] |
| KEGG Pathway | Galactose metabolism | |||
| Starch and sucrose metabolism | ||||
| Metabolic pathways | ||||
| Carbohydrate digestion and absorption | ||||
| Pathwhiz Pathway | Starch and Sucrose Metabolism | |||
| WikiPathways | Metabolism of carbohydrates | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6791). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment. Nat Commun. 2017 Nov 27;8(1):1785. | |||
| REF 4 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 5 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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