Target Validation Information
TTD ID	T85529
Target Name	T-cell-specific surface glycoprotein CD28 (CD28)
Type of Target	Successful
Action against Disease Model	Belatacept	Drug Info	Belatacept saturated CD80 and CD86 receptors in whole blood and dendritic cell cultures, although the belatacept concentrations required for CD86-receptor saturation were approximately 10-fold higher than those required for CD80 saturation (IC50=0.102 |?g/mL vs. 0.009 |?g/mL).	[1]
References
REF 1	Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation. Transplantation. 2009 Mar 27;87(6):926-33.

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